576 EXPERIMENT STATION RECORD. [Vol. 3o 



latent phase (incubation period), but the time can be controlled by increasing or 

 decreasing the quantity of vaccine used. The importance of individual varia- 

 tion in the production of immunity is noted. 



Studies on antibodies. — I, Analyses and nitrogen distribution of a number 

 of antisera, E. J. Banzhaf, K. Sugiuea, and K. G. Falk {Jour. Immunol., 2 

 {1916), No. 1, pp. 125-135). — This material has been previously noted (E. S. R., 

 36, p. 80). 



Experiments with oil of Chenopodium and cardiac stimulants on the iso- 

 lated frog heart, W. Salant and A. E. Livingston {Amer. Jour. Physiol., J^l 

 {1916), No. 1, pp. 21-38, figs. 10). 



A further report on thromboplastin solution as a hemostatic, A. F. Hess 

 {Joiir. Amer. Med. Assoc, 67 {1916), No. 24, pp. 1717-1720).— A number of cases 

 are reported in which an aqueous extract of ox brain was successfully used. 



It is concluded that the thromboplastin is of practical value in controlling 

 hemorrhage wherever it can reach the site of bleeding. In cases of true hemo- 

 philia it may be regarded almost as a specific hemostatic. Its use is indicated 

 in a variety of hemorrhages. In cases where local applications fail the throm- 

 boplastin solution should be injected into the site of hemorrhage. This pro- 

 cedure can be readily resorted to as the solution loses little of its potency as 

 the result of dilution and rapid boiling. 



In addition to its hemostatic action the extract was found to possess healing 

 properties, actively stimulating granulation and hastening epithelization. 



Spontaneous amebic dysentery in monkeys, A. Eichhoen and B. Gallagher 

 {Jour. Infect. Diseases, 19 {1916), No. 3. pp. 395-1,07, figs. 5). — This paper re- 

 ports upon a spontaneous outbreak of a disease in monkeys in which the lesions 

 corresponded closely to those found in amebic or tropical dysentery in man, and 

 in which protozoal organisms occuiTed that had the structure and character- 

 istics of those amebas generally considered the causative agents in human 

 tropical dysentery. 



The presence of Bacillus typhosus in the blood of rabbits after inoculation 

 into the gall bladder. Lange and Roos {Arb. K. Gsndhtsamt., 50 {1915), No. 1, 

 pp. 57-95). — In a very short time after inoculation of typhoid bacilli into the 

 gall bladder of rabbits the presence of the organisms can be detected in the 

 blood of the ear vein. This migration takes place directly at the point of 

 inoculation or in the immediate tissue through the blood capillaries of the gall 

 bladder. Such a rapid migration does not take place from other organs which 

 are equally as rich in capillaries. Injection of bile into the gall bladder facili- 

 tates the migration, while the subcutaneous injection inhibits it. By direct 

 injection into the liver a similar migration takes place. The animals which 

 have been inoculated in the gall bladder with the organisms become carriers of 

 the organisms, whether the migration was slow or rapid. Where the gall 

 bladder was extirpated shortly after the inoculation (six minutes) the animals 

 did not become carriers. 



In one animal typhoid bacilli were found in the urine 20 minutes after 

 inoculation. 



The etiology of Rocky Mountain spotted fever, S. B. Wolbach {Jour. Med. 

 Research, 34 {1916), No. 1, pp. 121-126, pi. 1). — The author reports the occur- 

 rence of a bacterium in large numbers in the lesions characteristic of spotted 

 fever in experimental animals. " The organism corresponds in some respects 

 with the description given by Ricketts of bodies which he found in the blood 

 of human and experimental cases, and in the tissues and eggs of infected ticks. 

 The classification of the organisms is not yet clear ; of its bacillary form and 

 multiplication by transverse division there can be no question." 



