182 EXPEEIMENT STATION RECORD. [Vol.38 



Studies in anaphylaxis, XXI, XXII (Jour. Immunol., 2 (1911), No. 6, pp. 

 525-556, 571, 572).— Continuing previous work (E. S. R., 38, p. 78), two studies 

 are here reported. 



XXI. Anaphylaxis in dogs. — A study of the liver in shock and in peptone 

 poisoning, R. Weil (pp. 525-556). — Results are presented which indicate a new 

 function of the liver, namely, its participation in the immune reaction. " This 

 participation does not appear to be indirect, as had previously been believed, 

 namely, by virtue of the toxic degradation of the antigen. On the contrary, 

 it is a direct and immediate reaction profoundly involving the functions and 

 structure of the organ. The accompanying general symptoms appear to be 

 merely accidental by-products of this reaction. . . . 



" It is perhaps needless to add that the hepatic reaction does not occur during 

 the course of the infectious diseases in the exaggerated form induced by the 

 anaphylactic experiment ; but that it plays a more subdued and continuous role 

 can hardly be doubted, in view of the direct evidence afforded by the study of 

 the blood in human serum sickness. Similar effects upon coagulability as de- 

 termined in anaphylactic guinea pigs lead to the belief that the liver is 

 probably a constant and important factor in the immune reaction throughout 

 the mammalia." 



XXII. Anaphylactic reactions of the isolated dog's liver, R. Weil and C. Eggle- 

 ston ( pp. 571, 572 ) . — This is a brief note of experiments which have been interrupted. 

 The results obtained confirm and extend the conclusions of the preceding study. 



Tissue transplantation and anaphylaxis, L. Loeb (Jour. Immunol., 2 (1917), 

 No. 6, pp. 557-569). — The results of the study reported show that the injection 

 of horse serum into animals into which have been transplanted the uterus and 

 thyroid from animals which were previously injected with horse serum does not 

 have any distinct influence on the life and growth of the transplanted piece, nor 

 does it noticeably alter the lymphocytic reaction on the part of the host tissue. 



In cases in which a second injection is made the general health of the animal 

 is affected and the transplanted piece may also suffer. " The lack of elTect of 

 the injections in the majority of the experiments does not -of course exclude 

 the possibility that with still further variations in dosage or time relations an 

 influence of the sensitization to horse serum may be demonstrable. It might be 

 especially desirable to repeat the experiment, choosing dosage and time of 

 injection in such a way that the second injection has a definite effect on the 

 general condition of the guinea pig. If it should again be found that in those 

 animals in which tlie second injection produces general effects the state of 

 preservation of the transplanted piece is interfered with, we would have to 

 decide further whether in this case we are dealing with a specific effect of the 

 injections on the transplanted piece or with a nonspecific effect, due to inter- 

 ference with the proper nourishment of the tissue as the result of circulatory 

 and general metabolic changes in the host." 



Anthrax, C. H. Higgins (Canada Dept. Agr. Health Anim. Branch Bui. 23 

 (1916), pp. 8). — A popular summary of information. 



Tuberculosis, with special reference to cattle and pigs, G. E. Bunning 

 ET AL. (Brisbane, Queensland: Govt., 1917, pp. 13). — This is a report of a com- 

 mittee appointed by the Queensland Committee of the Advisory Council of 

 Science and Industry. The questions reported upon are the preparation of a 

 tabulated statement of the loss directly attributable to tuberculosis, its rela- 

 tionship to the profitable conduct of mixed farming, the practicability of 

 building up an export trade in pork products, and the relationship of tuber- 

 culosis to the health of the community. 



Details to be observed in making a tuberculin test, G. Linch (Jour. Amer. 

 Yet. Med. Assoc, 52 (1917), No. 1, pp. 56-63).— The author discusses briefly cer- 



