1018] VETERINARY MEDICINE. 485 



may he readily infected witli T. equipcrduin and a severe anemia he produced. 

 The incuhation period varies from 3 to 8 days, and fatal termination results 

 in from 3 to 7 weeks. By successive transmission through dogs the vh-ulence 

 of the infection may be increased so that both incubation period and duration 

 of the disease may be shortened and the maximum anemia more quickly reached. 



" AVith the appearance of trypanosnmes in the circulating blood, the animals 

 show general weakness, loss of weight, lethargy, and a lessened tendency to 

 the healing of wounds?. Subcutaneous edema is a common manifestation and may 

 appear as a general anasarca or be limited to the genitalia or the extremities. 

 The edema fluid contains living trypanosomes. Another interesting and almost 

 constant lesion is keratitis. Choluria is constantly present without evidence of 

 jaundice in the skin or mucou.s niembrane. The anemia which develops is 

 progressive and of the hemolytic type. The hemoglobin may fall to 40, and 

 the red cells to less than 3,000,000 per cubic centimeter." 



Complenient fixation in experimental trypanosomiasis, A. C. Woods and 

 H. H. MoKRis iJo^ir. Infect. Diseases, 22 {1918), No. 1, pp. 7^.3-7,8). — "Dogs 

 infected with Trypanosoma eguiperdtim develop complement fixation with a 

 specific antigen within eight days after inoculation. An easily prepared and 

 a very satisfactory antigen is the salt solution extract of the .spleen of a rat 

 heavily infected with trypanosomes or dead from the infection. The comple- 

 ment fixation usually follows the appearance of trypanosomes in the blood, al- 

 though it may occasionally precede the appearance of trypanosomes. The com- 

 plement fixation, however, always antedates the appearance of symptoms. Dogs 

 infected with trypanosomes frequently give a positive Wassermann reaction. 



" Within three weeks after the appearance of trypanosomes in the blood, the 

 serum of the infected dog becomes strongly anticomplementary. This anti- 

 complementary phenomenon appears to be due to the liberation of anticomple- 

 mentary substances into the blood by the invading trypano.somes. The blood is 

 rendered sterile, and all clinical symptoms clear up following the intravenous 

 injection or arsenobenzol. In the only complete experiment at hand the anti- 

 complementary action and complement fixation properties with the trypanosome 

 and Wassermann antigens likewise disappeared." 



Concerning the trypanosome of swine in the valley of the Inkissi, J. 

 Greggio {Bui. Agr. Congo Beige, 8 {1911), No. 1-2, pp. I48-I6O).— In the valley 

 of the Inkissi 36 of 94 domesticated swine examined were found to carry Try- 

 panosoma congolense, a human trypanosome, but for them it does not appear 

 to be pathogenic. 



Studies of the tissue reactions to various products of the tubercle bacillus, 

 P. F. MoKSE and Ethel Stott {Jonr. Lab. and Clin. Med., 2 {1916), No. S, pp. 

 159-167, pi. 1, figs. 7). — This article reviews the literature on the mechanism of 

 the formation of the tubercle, the predominant theory of previous investigators 

 being that the histological lesion caused by the tubercle bacillus is due to a 

 poison liberated from the body of the bacillus by action of the tissue cells. 

 The present investigations, which are described in detail, suggest that the lesion 

 is due rather to the waxy substances of the bacillus acting as a peculiar type 

 of foreign body. 



A study of the relative efficiency of the various differential staining 

 methods used in identifying the tvibercle bacillus, N. P. Sherwood {Kans. 

 Univ. Sci. Bui, 10 {1917), No. S, pp. 25-S5). — The author's investigations have 

 led to conclusions of which the following form a part : 



" There is great variation in the acid-proofness of different strains of Bacillus 

 smegniatis. Even in positive sputums there is some tinctorial difference of the 

 tubercle bacillus toward Fonte's stain, whereas with the other methods very 



