610 EXPERIMENT STATION RECORD. 



the other 2 were kept as control animals. The vaccinated animals received grad- 

 ually increasing doses of a suspension of a culture of human tubercle bacilli. In all, 

 125 cc, representing about 0.16 gm. tubercle bacilli, were administered to each ani- 

 mal. All 4 of the animals were inoculated on July 29 following, by an intratracheal 

 injection of 10 cc. of a suspension of bovine tubercle bacilli known to be virulent for 

 cattle. 



All of the animals were killed on different days of the following October and care- 

 ful post-mortem examinations were made. Both of the control animals were found 

 to be extensively infected with tuberculosis and exhibited fresh tubercles which 

 were evidently in a progressive state. In one of the vaccinated animals it was found 

 that all the organs, with the lymphatic glands and covering membranes, were free 

 from disease, with the single exception of a slight fibrous thickening at the point of 

 vaccination. The second vaccinated animal exhibited 2 hard globular thickenings 

 at the point of inoculation, and within the trachael mucous membrane 2 minute 

 grayish elevations were found, the smaller one of which contained caseous material. 

 All the other organs were in a healthy condition. 



From these experiments it is concluded that by means of repeated intravenous 

 injections of human tubercle bacilli, the resistance of young cattle to virulent bacilli 

 of bovine origin may Ije greatly inci-eased — to such an extent, in fact, that the ani- 

 mals are not affected by inoculations capable of causing death or extensive infection 

 in cattle which have not been thus protected. Intravenous injections of much larger 

 quantities of human tubercle bacilli than are necessary to confer resistance upon the 

 vaccinated animals may be safely given. The authors have other experiments in 

 progress for the purpose of determining the duration of immunity thus produced and 

 the effectiveness of the method in protecting animals against natural infection. 



Is the ingestion of the meat of tuberculous animals dangerous for human 

 beings? V. Galtier {Jour. Med. Vet. et Zooiech., 5. ser., 6 [ISOi'), Jan., pp. 1-7). — 

 The author discusses the various conditions under which different animals may become 

 infected with tuberculosis. In this discussion especial attention is given to the 

 different degrees of susceptibility to the disease. Brief notes are presented on a 

 number of experiments conducted by the author since 1891 bearing upon the ques- 

 tion at issue. The author concludes from his experiments that regulations regarding 

 meat inspection should be modified so as not to require the seizure and destruction 

 of the meat of all tuberculous animals, but only the meat of animals which exhibit 

 pronounced emaciation or extensive tuberculous lesions in the muscles and bones. 



On the question of indemnity to butchers for animals found to be tubercu- 

 lous after slaughter, V. (Jai.tier {Jour. Med. 17/. et Zootech., 5. ser., 6 {190J), Mar., 

 pp. li!9-143). — The author presents a detailed discussion of this question with especial 

 reference to the French law of July 3, 1895. Many difficulties h^ve been found in 

 attempts to adjust differences arising from the sale of tuberculous cattle to butchers. 

 It is argued that all sales of cattle for butchering should be made subject to the 

 regulations of this law and that legal contests which may arise should be settled in 

 accordance with its jirovisions. 



The history of a tuberculous herd of cows, C. L. Beach ( Connecticut Storr.'i 

 Sta. Bid. ii4, pp. 24, figs. 6). — This bulletin contains observations on the station herd of 

 about 50 cows and young cattle. The herd was tested with tubercuhn in 1896 and w-as 

 found to be free from tuberculosis. The test was again applied in 1897, without any 

 reaction. During 1897 a Guernsey cow was bought from a neighoring farmer. The 

 cow did not react to tuberculin test. In the following year, however, this animal 

 suddenly exhibited symptoms of disease. A post-mortem examination showed a case 

 of generalized tuberculosis. The herd was then tested with tuberculin and 12 ani- 

 mals responded, and later 6 other animals responded to the test, making a total of 

 18. Five of the affected animals were killed and examined; the remainder were 



