706 EXPERIMENT STATION RECORD. 



diseases occur, liovvever, which closely resemble it. In the case of one of these dis- 

 eases abscesses are found in the walls of the nasal cavity, while in the other the 

 most conspicuous symptom is violent fits of coughing. The cough is dry and of a 

 hollow sound, and the animals cough 10 to 16 times in rapid succession. In one 

 outbreak 50 animals were affected with this disease, and all recovered. Apjiarently 

 no pathological lesions were produced. The author is unable to explain the physi- 

 ology of these two affections. 



Treatment of contagious coryza by colloidal silver, Baumgart {Berlin. 

 Tk'urarzll. Wchnsdw., 1902, No. S, jtp. 3D, 40). ■ — The author made an extensive teat 

 of the efficiency of this remedy in treating contagious coryza. The results were neg- 

 ative and in some instances indicated a harmful effect of the silver preparation. The 

 author concludes that in slight cases of contagious coryza good results may be 

 obtained without the use of colloidal silver, and that in more serious cases combined 

 with sepsis or pneumonia, the colloidal silver exercises no beneficial effect upon the 

 coui'se of the disease. 



Successful treatment of tetanus with a sIoav course by means of antitetanus 

 serum, Maechal {Rec. Mid. Vet., Paris, S. scr., 9 [1902), No. l,pp. ifi-l-O).— Detailed 

 notes are given on the symptons of a case of tetanus in a mare 6 years of age. During 

 an outbreak of conjunctivitis among horses the mare in question was observed to be 

 affected with this disease. Recovery took place after a few days, and later, symp- 

 toms of tetanus appeared. At first 50 cc. of antitetanus serum was given in a hypo- 

 dermic inoculation. Other injections of serum in similar doses were repeated. 

 Various drugs were also administered, such as chloral hydrate in doses of 60 gm., 

 bromid of jjotash in doses of 10 gm. night and morning, and morphin. Recovery 

 took place 23 days after the appearance of the symptoms. No lesions were i)roduced 

 by the antitetanus serum at the point of inoculation. 



A new method of cultivating the tetanus bacillus, L. Debrand (Ann. Inst. 

 Pasteur, 16 {1902), No. 6, pp. .^;?7-.^5i') .—The author made cultures of tetanus bacillus 

 in symbiotic relation with B. subtilis. The association of the 2 species of bacilli in a 

 single culture has the one practical advantage that when associated with B. subtilis 

 the tetanus bacillus develops under aerobic conditions; otherwise, it is anaerol)ic. 

 The serum of animals which have been immunized with a toxin prej^ared from mixed 

 cultures of these 2 species of bacillus was tested in order to determine whether it 

 possessed any antitoxic properties. Two series of experiments were conducted, in 

 one of which animals received the serum before the toxin, and in the other, received 

 the toxin before the serum. During these experiments it was found that a toxin 

 obtained by a culture of tetanus bacillus in symbiosis with B. subtilis may be used to 

 produce a serum in experimental animals which is as active as that obtained by the 

 ordinary methods of cultivating tetanus bacilli. 



The action of dry heat on the spores of tetanus bacillus, Y. Morax and 

 A. Marie {Auii. Tnst. Pastevr, 10 {1902), No. 0, ])j>. 4IS-420). — The authors' experi- 

 ments on this problem may be briefly summarized as follows: The tetanus bacillus 

 was cultivated in symbiosis with B. subtilis. It was found that after heating cultures 

 for 20 minutes at a temperature of 152° C. the spores of the tetanus l)acillus were 

 destroyed, while those of B. .subtilis did not develop within 24 hours. A tempera- 

 ture of 155° C. for 20 minutes did not kill the spores of B. subtilis, while those of the 

 tetanus bacdlus were destroyed. Dry heat was found to reduce the vitality of the 

 spores of tetanus bacillus and the virulence of the tetanus toxin in a rapid manner. 



Glycosuria in rabies, its importance in diagnosing this disease, A. Rabieaux 

 and E. Nicolas {.Jour. Med. ]'ct. ct Zonleeh., .5. srr., {1902), Jan., pp. 16-2S).— An 

 extensive series of experiments M'as conducted by the authors for the purpose of 

 determining how constant a symptom of rabies glycosuria could be considered. As 

 a result of these experiments it was found that in carnivorous animals glycosuria is 

 a very frequent symptom of rabies, but unfortunately is not constant enough to serve 



