VETERINARY SCIENCE AND PRACTICE. 511 



there is never a true acclimatization to the effect of tuberculin, but that the reaction 

 to a second tuberculin injection, occurs so promptly and lasts so short a time that it 

 is usually overlooked. In order to prevent any deception on the part of cattle 

 vendors in making the tuberculin test, it is recommended that the inoculation be 

 made about 5 or 6 o'clock a. m. and that approximately twice as large a dose be used 

 as ordinarily, 8 cc. being considered a satisfactory dose for susceptible cattle. The 

 temperature should then be taken at intervals of every 2 hours for a period of about 

 14 hours. 



An experimental study on - the effect of the blood sera of normal and 

 immunized goats in modifying the progress of tuberculous infection, A. G. 

 Nicholls (Proc.and Trans. Roy. Soc. Canada, ?.ser.,9 I 1903-4), IV, pp- 3-33). —The 

 first observations relating to the agency of blood serum in checking the progress of 

 tuberculosis were published by Hericourt and Richet in 1888, since which time a 

 number of experiments have been made by other investigators along similar lines. 

 The author studied the properties of normal and immunized goat serum as related to 

 the progress of tuberculosis. 



It was found that goats are relatively quite immune to tuberculosis and that the 

 normal blood serum of goats contains a correspondingly large number of antitoxic 

 units. In the first series of experiments several guinea pigs and rabbits were inocu- 

 lated with mildly virulent tubercle bacilli and also treated with normal goat serum. 

 Detailed notes are given on the history of each of these cases. It was found that 

 tubercle bacilli were not disseminated to a distance from the site of the original inoc- 

 ulation with any of the treated animals. A second series of experiments were made 

 on another lot of guinea pigs and rabbits, which were inoculated with a more viru- 

 lent culture of tubercle bacilli. In these cases injection of normal goat serum had 

 no effect in checking the disease in guinea pigs, but in rabbits such a result was 

 noticeable. 



Since the blood of healthy goats appears to be considerably antitoxic, the author 

 attempted to intensify this property by inoculating healthy goats with gradually 

 increasing doses of Koch's new tuberculin. Experiments were then carried out in 

 testing the effect of the serum of such goats upon the progress of tuberculosis in 

 rabbits. 



As a general result of the author's studies it is concluded that the injection of anti- 

 toxic goat serum exercises a certain amount of restraining influence upon the extent 

 and development of tuberculosis. This influence, however, is not enough to prevent 

 entirely the extension of the disease. Normal goat serum injected into guinea pigs 

 and rabbits is almost harmless and rarely produces any hemolysis. It appears to 

 stimulate the nutritive processes and possess a slight antit< >xie power against tubercu- 

 losis in rabbits. The natural antitoxic power of goat serum may be considerably 

 increased by repeated injections with Koch's new tuberculin. The injection of this 

 serum exercises no effect upon the temperature of the animal. A bibliography 

 relating to serum treatment of tuberculosis is appended to the article. 



The control of bovine tuberculosis (Verslag. Meded. Afdeel. Landb., Dept. 

 Waters!. , I In i,<1. , Nijv. , 1904, No. 3, pp. SO, pis. 3). — In this pamphlet a general account 

 is given of the present status of bovine tuberculosis in Holland, together with an 

 account of the appearance of the disease in various organs and tissues. Notes are 

 also presented on the losses from this disease, its distribution, and the means which 

 have been adopted for controlling it in Denmark, Norway, Sweden, Belgium, 

 France, and the Netherlands. 



Texas fever in the Philippine Islands and the far east. The Australian 

 tick (Boophilus australis) in the Philippine Islands, J. W. Jobling, P. G. 

 Woolley, and C. S. Banks (Philippine Dept. Int., Bureau Govt. Labs. [Pw&.], 1904, 

 No. 14, pp. 21, pis. 24, figs. 4). — In November, 1903, some cattle purchased in Cali- 

 fornia north of the Texas fever quarantine line were landed in Manila and were 



