(U)2 EXPERIMENT STATION RECORD. 



and contain special articles by a large number of well-known authorities on various 

 subjects. 



Volume 1 contains a general account of tbe historical development of the doctrine 

 of infection, immunity, and prophylaxis together with a discussion of the general 

 morphology and biology of pathogenic micro-organisms, nature of infection, mixed 

 infection, bacterial toxins, transmission of infectious diseases, bacteriological methods, 

 lower pathogenic fungi, malarial parasites, hemoglobinuria of cattle, and pathogenic 

 protozoa. Volume 2 is occupied with exhaustive accounts of anthrax, tuberculosis, 

 fowl cholera, hemorrhagic septicemia, tetanus, blackleg, malignant edema, braxy, 

 glanders, actinomycosis, and various diseases which chiefly affect man. 



Volume 3 includes discussions of swine plague, hog cholera, swine erysipelas, 

 pleuro-pneumonia, contagious coryza, mouse typhoid, pseudotuberculosis, calf dys- 

 entery, infectious abortion, infectious vaginitis, fowl plague, and numerous related 

 human diseases. Volume 4 contains a general discussion of the prophylaxis of 

 infectious diseases, disinfection, natural immunity, protective vaccination, theories 

 of immunity, antitoxic and bactericidal sera, specific precipitins, agglutinins, and 

 special accounts of the methods of producing immunity in a large number of diseases 

 of man and animals. 



Hemagglutinins, A. Bexheft {Arch. Physiol. [Pfluger], 104 (1904), No. 3-4, pp. 

 235-24®)- — A brief review is given of the literature relating to this subject. The 

 author conducted a number of experiments with normal blood serum from cattle and 

 swine. During these experiments it was found that by using the proper quantity of 

 swine blood all substances which agglutinated blood corpuscles of hogs could be 

 removed from normal blood serum of cattle. This removal of the hemagglutinins 

 from cattle-blood serum requires uniformly the same quantity of swine blood. 



It was found impossible by means of physiological salt solution to extract from the 

 agglutinated swine-blood corpuscles hemagglutinins which would in turn agglutinate 

 fresh hog corpuscles. From these results it is concluded that in normal cattle-blood 

 serum there exists a special substance which has the power of agglutinating the blood 

 corpuscles of hogs, and that this substance becomes chemically combined with the 

 red blood corpuscles of swine, otherwise it could be again extracted by means of a 

 physiological salt solution. 



Influences of ingestion of bacteria and bacterial products on the prop- 

 erties of blood serum, A. Tchitchkine (Ann. Inst. Pasteur, 18 (1904), No. 9, pp. 

 576-586). — The literature relating to this subject is briefly reviewed. The author's 

 experiments were made on adult and young rabbits. The rabbits were fed bran and 

 green herbage in summer and bran with carrots in winter. In order to change the 

 bacterial contents of the intestines as far as possible mixtures of milk and bran were 

 fed. After accustoming the rabbits to the conditions of the experiments they were 

 fed various quantities of typhoid bacilli with their ordinary rations. 



It was found during these experiments that the serum of adult, normal rabbits as 

 well as that of young rabbits frequently possesses feeble agglutinating properties 

 toward the typhoid bacillus. No disease resembling typhoid can be produced in 

 rabbits by feeding them typhoid bacilli. The ingestion of large quantities of these 

 organisms, however, influences to a considerable extent the properties of the blood 

 serum. The presence of agglutinins and precipitins is noted after such treatment. 

 The serum then possesses considerable preventive properties as regards typhoid fever. 

 The ingestion of typhoid bacilli killed by heat gives similar results, but the changes 

 in the blood serum are less pronounced. 



The further differentiation of flagellar and somatic agglutinins, H. G. 

 Beyer and A. L. Reach (Jour. Med. Research, 12 (1904), No. 3, pp. 313-328).— 

 Experiments were carried out by the authors in attempting to determine any possible 

 differences between the agglutinins obtained from the flagella and the bodies of 

 typhoid and hog-cholera bacilli. Rabbits were used as experimental animals. 



