§ I EXAMINATION OF BITTERLING HYPOPHYSIS 



53 



Androsterone 



8 10 12 14 



Fig. 47. Ratio between the quantity of basophile pituitary cells and 

 corpora lutea in the a and /? stages after administration of androsterone. 



This extrusion was followed again by restitution, which was 

 studied for 10 hours. Corresponding to the rapid fall in the 

 hypophysis curve, there was a reciprocal rise in the curve 

 representing the phases of the corpora lutea. When this 

 increase was completed, transformation into the «-, and then 

 into the /5-stage continued, so that the four successive maxima 

 and minima are shown in the respective curves. 



While in the ovary the different phases of the corpus 

 luteum succeed one another there is further secretion of hor- 

 mone by the hypophysis. The restitution phase, after admin- 

 istration of progesterone, last i^ hours; after androsterone 

 (vide Fig. 47), 3 hours; after estradiol (vide Fig. 48), 7 

 hours. After this first restitution the hypophysis is filled 

 again sufficiently with luteinising hormone to enable the 



26 28 

 hours 



a 2 4 6 8 10 12 14 16 18 20 22 24 



Fig. 48. Ratio between the quantity of basophile pituitary cells and 

 corpora lutea in the a and ^ stages after administration of estradiol. 



