392 EXPEKIMENT ^iTATION RECORD. 



rabbits. The experimental animals were infeoterl by feeding with tuberculous mate- 

 rial or l)y intravenous injections. The check animals were infected in the same 

 manner. The results of these experiments may be summarized as follows: The 

 treatment of tuberculosis by the simultaneous use of Fowler's sohition and a solution 

 of strychnin indicated some action of these substances in checking the progress of 

 the disease. The experimental animals remained in a better condition of health 

 than the check animals and it was determined that the progress of the disease was 

 much hindered, and that the lesions showed a tendency to disappear. The same 

 treatment adopted for the purpose of prevention increased the resisting powder of 

 animals to the disease, prevented the generalization of infection, and brought about 

 a cicatrization or extinction of already-e5cisting lesions. During these experiments 

 it was found that a solution of strychnin given in suitable doses in the food or water, 

 or in subcutaneous injections, had no injurious effects upon the experimental ani- 

 mals. The ass and pig showed an especial resisting power to relatively large doses 

 of strychnin. The guinea pig was much more resistant than rabbits. It is con- 

 cluded that strychnin in suitable doses may be advantageously administered either 

 alone or associated with ar.senic in the treatment of tuberculosis. 



Government regulations to be adopted for tlie eradication of tuberculosis 

 in domestic animals, KtrnxAU {Berlin. Tlmmrztl. Wchnschr., 1901, Xo. 7, pj>. 

 llS-liO). — For the government regulation of this disease the author recommends 

 periodical milk inspection, compulsory reporting of tul)erculosis of the udder, and 

 destruction and indemnity for such cows, pasteurization of dairy products, control of 

 the manufacture and <listri])ution of tuberculin, and prevention of importation of 

 tuberculous cattle an<l untreated milk. 



The struggle against bovine tuberculosis, B. B.\xg ( Ontario Acjr. Col. rind Erpt. 

 Farm Rpt. 1900, pp. 81-95). — A translation by F. C Harrison of certain portions of 

 Professor Bang's writings on tuberculosis. 



A new method of tubercle-toxin treatment, (i. Laxdmaxx {Hyg. Rundschau, 

 10 {1900), No. 8, pp. 361-.376). — The author experimented with a compound which 

 he calls tuberkulol. The method of preparation is as follows: Bouillon cultures of 

 tubercle bacilli which have been brought to a high degree of virulence by repeated 

 passages through animals, are filtered, and then the fat is extracted and the bacilli 

 are pulverized. They are then extracted by the fractional method in physiological 

 salt solution, beginning with a temperature of 40° C. and ending with a temperature 

 of 100°. 



Numerous experiments were made with this substance on animals and on tuber 

 culous human patients. From these experiments tTie author concludes that tube" 

 kulol is much more active than any similar product produced, and that healthv 

 animals can be immunized by injections of this substance, so that they are protected 

 against subsequent infection from tuberculosis. Satisfactory results were also 

 obtained from hypodermic injections of tul)erkulol in tuberculous human patients. 



Culture of tubercle bacillus, C. Fraexkel {Hijg. RtrndKchati, 10 {1900), So. 13, 

 pp. 617-fj30). — The author records the results of experiments in making cultures of 

 the tuljercle bacillus upon a great variety of different media of different reaction, 

 concentration, and chemical composition. 



Pathogenesis and therapy of milk fever, C. Hemprich {Berlin. Thierurztl. 

 Wchnschr., 1901, Xo. 0, pp. 90, 91). — According to the author, milk fever is caused 

 by a process of autointoxication, which is due to the production of "milk radicals." 

 These milk radicals appear in abundance at the beginning of the process of milk 

 secretion and antagonize the action of the liver. It is not determined whether the 

 milk radicals are derived from the sugar, fat, or casein of the milk. In the treat- 

 ment of milk fever, the object should be to check the milk secretion until the liver 

 can metamorphose the abundant milk radicals. The author used a modification of 



