590 EXPERIMENT STATION RECORD. 



The mechanism of ag-glutination, A. Joos {Ztschr. Hijg. n. Trifecthnskranl-., 36 

 {1901), No. 3, pp. 422-439). — This paper is concerned with the discu^^sion of results 

 obtained from experiments in agghitination with and without the addition of common 

 salt. The experiments were made with the tj-phus bacillus. The results of the 

 experiments may be briefly summarized as follows: When an agglutinating serum is 

 brought in contact with a substance which is subject to agglutination, no agglutinat- 

 ing process takes place in the absence of salt. When salt is added, agglutination 

 occurs readily. In the absence of salt the agglutinating serum is entirely sterilized 

 by the action of the bacilli, without producing any change in the vitality of the 

 latter. A close connection exists between the relative quantities of the substances 

 which cooperate to i^roduce agglutination and the substances which are to be agglu- 

 tinated. The i^rocess of agglutination may occur in a solution which is free from salt, 

 provided the bacterial cells contain some of this substance. 



Coagulation of the blood and anticoagulation serum, J. Bordet and 

 O. Gexgou {Ann. Inst. Pasteur, 1.5 {1901), No. 3, jyp- 129-144). — During these experi- 

 ments it was found that the blood plasma of birds is poor in fibrin ferment and serves 

 as a convenient reagent for checking the action of fibrin ferment in the blood sera of 

 several species of mammals. The blood plasma of rabbits can be i)reserved without 

 undergoing coagulation in a tube sealed with i^aratfin, but coagulates rapidly in 

 contact with roughened glass. It was found that when one animal was injected with 

 the blood plasma or serum of a second siiecies, a serum was obtained which had the 

 effect of neutralizing the fibrin ferment of the second species. 



Experimental vaccine, A. Calmette and C. Guerix {Ann. Inst. Pasteur, 15 

 {1901), No. 3, pp. 161-168). — During the researches reported in this article it was 

 found that an inoculation of rabbits with vaccine was uniformly followed with erup- 

 tion of small pustules containing large quantities of lymph. The rabbit proved to be 

 a useful animal in this study, since it is possible to verify readily by inoculations 

 into rabbits the relative degree of virulence of vaccines obtained from different sources. 

 By injecting vaccines into the peritoneal cavity of rabbits, the micro-organisms 

 contained in such material are destroyed by the leucocytes without influencing the 

 virulence of the virus. 



A study of Bacillol, F. P.\szott.\ {Monat. PmJd. Thierh., 12 {1901), No. 6-7, pp. 

 241-275). — A description is given of the general properties of this substance. Numer- 

 ous experiments were conducted in testing its antiseptic power in the treatment of 

 mange, other skin diseases, surgical wounds, and in determining its toxic action. 

 During these experiments it was found that Bacillol is soluble in water and that the 

 solutions are constant. When used on the skin in a concentrated form it is slightly 

 irritant, like lysol. Its antiseptic and deodorizing properties are pronounced. When 

 administered internally, it causes an increased secretion of saliva, the respiration and 

 pulse are increased, but the temperature is lowered. In large doses it causes a motor 

 paralysis. The fatal internal dose of this substance is so large that all danger in its 

 practical application is avoided. A bibliography of the subject is added. 



Therapeutic contributions in veterinary science during the years 1898, 

 1899, and 1900, E. B.\ss {Deut. TMeriirzil. Wchnschr., 9 {1901), No. 12, pp. 120- 

 133). — The author gives a brief digest of the therapeutic literature along veterinary 

 lines and in connection with bibliographical references. 



Antitoxic treatment of tetanus, J. .Storie ( Vet. Jour., n. ser., 3 {1901), No. 16, 

 pp. 201-20')). — Six cases of tetanus were treated by this method with a complete 

 recovery in 5 cases. The cases were all severe, and the author believes the most of 

 the animals would have succumbed without this treatment. 



The primary effect of the tubercle bacillus, F. Wechsberg {Beiir. Path. Anat. 

 u.Allg. Path., 29 {1001), No. 2, pp. 203-232, ph. 2). — This paper is concerned with a 

 discussion of the question of what cells take part in the formation of the tubercle. 

 An elaborate critical review is given of the literature of the subject and a report is 



