IGNATIA AMARA. -! 



five minutes he commenced to pant ; fifteen minutes afterwards 



symptoms of convulsions appeared ; and in about half an hour 



he fell down in an attack of tetanus, the intellectual faculties 



being unimpaired. The animal died asphyxiated in about 



twenty minutes after the tetanic symptoms came on. 



In another experiment, six grains sufficed to kill a large- 

 sized dog. 



Orfila mentions that the extract of Ignatia injected into the 

 veins, or applied externally, acts in the same manner as the 

 upas and the nux vomica. 



On Man. — Camilli {Phil. Trans. 9 vol. xxi. p. l(5i)9) reports 

 that a man suffering from dyspepsia, being attacked with vomit- 

 ing and diarrhoea, took a scruple of the powder of Ignatia. He 

 was soon seized with excessive irritation and severe convulsive 

 movements ; his jaws were closed ; the muscles of the face were 

 drawn in different directions, as if the person was convulsed 

 with laughter. 



A paralytic stiffness in the low^er limbs, with involuntary 

 twitchings in them, great anxiety, coldness of the whole body, 

 with dilatability of the pupil, etc., were the symptoms produced 

 in a youth of twenty years by an over-dose of Ignatia; his 

 head was free, his consciousness perfect, but on account of the 

 anxiety he could not express himself properly. He was com- 

 pletely restored by drinking eight ounces of vinegar in the 

 course of half an hour {Hahnem. Less. Writ, p. 379). 



Loureiro {Flor. Cochinch,, vol. i.) states that giddiness and 

 violent cramps were produced by thje use of this drug, which 

 were relieved with lemon-juice and cold water. 



A man, forty years old, took, after tertian fever, half of a 

 bean of Ignatia in brandy. He had numbness of his ex- 

 tremities, violent, general, convulsive cramps, with great per- 

 spiration. 



Jorg {Mat. zueiner Neaen Arzneim., 1624) made the following 

 experiments with Ignatia ; one ounce of the powder mixed with 

 one ounce of wine : 



B 



