107 



K.rpcf'niu'iifs oil the pre I'ciif'/on of hot/ rliolcm hi/ niociihit'/on . — • 

 Under this head arc iiixcii the results oi" exi)erinieiits. with no attempt 

 to discuss the i:-enerai eeononiic A'ahie of \accinat ion in such diseases. 



I nociildfioit ir'itJi snidll doxcs of xfroiif/ rims in the foi-ni of ll</ui<i 

 '■nlfnres. — A considcrahh' nuniher of experiincnts show that a dose of 

 one-fifth cul)ic centinieter of culture liquid may he injected liypo- 

 derniically without daii<>-er to the life, of the aninuil. After the 

 effects of the inocuhition have ])assed. a lai'ii'er dose. reachini>- 2^, to )] 

 cubic centimeters, may also be i>"iven in the same way without danii'er. 

 ^lost animals thus inoculated contracted hoi>' cholera when they 

 were af'tei'wards exposed either by feedino' or by coliabitatino; with 

 diseased piii's. 



Effect of fccdiiKj snidll (jniinfitics of /■n/fiircs. — A nunilter of [)il2.'s 

 were i\'d with from 10 to 100 cubic centimeters of cidture li(|uid. 

 These animals Avere more or less affected by the feeding, but none 

 died. AMieii they were afterwards placed in an infected pen all con- 

 tracted the disease and died. There was a marked ditFerence between 

 the ])iii-s which had been fed and the check animals, in that the latter 

 died of most severe hemorrhagic type of the disease, while the former 

 -iiccumbed to chi'onic infection. 



Injection of sterilized culture liquid to produce immuirity. — The 

 ohlest ex])eriments were made in ISS.") and 1S8G with pigeons, and 

 were continued in 1SS7. They show tliat these l)irds could l)e made 

 insuscej^tible by such treatment. A considerable inimber of tests with 

 stei-ili/ed cultures were made npon pigs, but without any nniformly 

 fa\()rabh' i-esult, although in some cases there appeared to be more 

 oi" h'ss innnunity ]:)roduced in this way. 



K.r pcrinicnts on the attenu<(tion of lioij-cholcnt haeilll hi/ heat. — 

 These ex])eriments indicate that the ])athogenic power of the bacilli 

 expire- ordy with their lives. The attempts therefore at attenuation 

 were not successfnl, but they Avere being continued at the time the 

 re])()rt was written. 



FIo(/ cjiolcni. or disco ftcs closely allied to it, in other countries.— 

 Uiuler this head is given a condensed sunnnary of literature relating 

 to the sAvine fe\-er of (Jreat Ui-itain, a disease of swine in Denmark 

 resembling hog cholera, and also outbreaks in France believed to be 

 of the same natiu'e. 



Report on epizootic niSE.\Sf:s amonm; swixe. liv the United States 

 lioAR!) or Inquiry (pp. 5-lo). — This board, consisting of Dr. P]. O. 

 Shakespeare, of Philadelphia, Pa.: Dr. T. d. liurrill, of Champaign, 

 TIL. and Dr. V>. Meade Bolton, of Uobnnbia, S. U.. was appointed by 

 the Conunissioner of .Vgi-icnlture to decide certain contested ques- 

 tions in regai-d to swine diseases and as to the accuracy of the scien- 

 tific woi'k td' the Uureau of Animal Industry. The board \isited 

 Washington. I). C. Uolumbia. S. C., Lincoln. Xebr., Lexington. K3^, 

 and Cohunbus, Ohio. There are two reports, one signed by Dr. Shakes- 



