460 



RADIATION INJURY AND LETHALITY 



apparently different types are shown here. The first is the lymphoma 

 responses in susceptible mice given x-ray dosages (40), expressed first 

 as the directly observed Gompertz function (Fig. 12), then as the loga- 

 rithmic increment above the normal Gompertzian incidence (Fig. 13). 



2.00 



-0.25 - 



-0.50 



100 200 300 400 500 600 



Time after beginning of treatment, days 



700 



Fig. 13. The data of Fig. 12, plotted here as the difference of Gompertzian values of 

 treatment groups and controls. When so expressed, the radiation specific lymphoma 

 response is seen to be monophasic, rising to a maximum at 150 days and then sub- 

 siding to control level. The form of the response is the same at all dosage levels. 



When expressed in this latter form, the lymphoma response appears to 

 be a monophasic linear process, since the responses to the three doses 

 have the same time pattern and differ only in amplitude. This suggests 

 that the incidence of lymphoma may be a rate process, governed by a 

 fundamental injury process consequent to irradiation. 



The second type is the bone-tumor response in Sr^^-treated mice, 



