121 



ked development of endothelo'id giantcells, in some places with 

 lobed nuclei, and proliferation of fibroblasts with both fine and 

 patchy sclerosis. Eosinophil cells were found only occasionally 

 (apparently due to exhaustion of the marrow as indicated by 

 marrow sections). 



The spleen showed a heperemic tumor, pulp and sinuses 

 being filled with red bloodcells. In addition the malpighian 

 corpuscles showed a lesion distinct from the usual hyperplasia 

 which results in a sharp outlining of the germinal center and 

 a thick collar of lymphocytes. In this spleen however there 

 was irregular and extensive proliferation of the endothelo'id 

 cells with numerous mitotic figures present. Many of the cells 

 were of the size and charakter of the endothelo'id giantcells in 

 the lymph-nodes. There was also some fibroblastic prolifera- 

 tion in and adjacent to the corpuscles. A scattering of eosi- 

 nophils was seen. 



A the post-mortem examination a culture was taken from 

 the axillary lymph-nodes, and a pure culture of the diphtheroid 

 organism was obtained«. 



Zusammenfassend schreiben sie: 



»Thus, since our experiments demonstrate that the diphthe- 

 roid organism is pathogenic for the monkey, that it produces 

 a progressive enlargement of the lymph-nodes, with lesion 

 similar to those of HODGKIN's disease in man, and further 

 that the blood-changes in the monkey are similar to those in man, 

 we feel fully assured of the etiologic relationship of the diph- 

 theroid organism (Bacterium HODGKINl) to HODGKIN's disease«. 



Leider sucht man vergebens in diesen Mitteilungen die 

 Reproduktionen der mikroskopischen Präparate, welche freilich 

 gerade für dieses Krankheitsbild mehr noch als die Beschrei- 

 bung überzeugenden Einflusz hätten geltend machen können. 



Wenn diese Resultate Bestätigung finden werden, dann 

 sind wir gewisz eine grosze Strecke auf dem Weg zur 

 Kentnis des malignen Granuloms weiter gekommen. Aber auch 

 dann noch stehen wir Fragen gegenüber, die teilweise zu 

 beantworten ich mir im Folgenden zum Zweck gesteht habe. 



