Î20 



den Forschern BUNTING & YATES »), BILLINGS & ROSENOW 2), 

 VERPLOEGH, KEHRER & HOOGENHUYSE 3) Corynebacteriën 

 aus allen ihren Fällen von malignem Granulom zu züchten. 



Während es uns bei einer ganzen Reihe von Tierexperi- 

 menten die Krankheit des malignen Granuloms bei Tieren zu 

 erzeugen durch Einverleibung des gezüchteten Corynebacteriums 

 nicht gelungen war, sollen BUNTING & YATES, laut ihrer 

 Mitteilung in einer »Preliminary note« 4 ), bei Affen (Makakus 

 Rhesus) in Drüsen regionnär an der infektirten Stelle dem 

 frühesten Stadium des malignen Granuloms bei Menschen sehr 

 ähnliche Bilder gefunden haben, und laut Mitteilung in einer 

 »second note« 6 ) durch Transplantation dieser Drüsen bei anderen 

 Affen derselben Art eine Allgemeininfektion mit dem Bilde des 

 malignen Granuloms in Drüsen und Milz erzeugt haben. 



Ueber die Allgemeininfektion geben sie folgende Beschreibung: 



»Post mortem examination showed in right axilla a group 

 of enlarged lymphnodes, from 10 to 5 m.m. in diameter, with 

 softened areas from which, on incision, a thick puriform necrotic 

 material was expressed. Extending upward from these nodes 

 was a suppurative process reaching to the highest point in the 

 axilla and involving the chest wall. The organs showed multiple 

 metastatic abscesses in lung, heart, liver and pancreas. Aheperemic 

 splenic tumor and cloudy swelling of the viscera were present. 



Histologically, while the areas of necrosis and leukocytic 

 infiltration were the most prominent feature of the picture in 

 the adjacent parts of the nodes, there were all the elements 

 of the HODGKIN'S picture : distortion and disappearance of 

 architecture ; great proliferation of endothelo'id cells, with mar- 



*) Bunting, C. H. and Yates, J. L., Cultural Results in Hodgkin's Disease. 

 (The Arch, of Int. med., Vol. 12. 1913.) 



2 ) Billings, F. and Rosenow. E. C. The Etiology and Vaccine Treatment 

 of Hodgkin's Disease. (The Journ. of the Am. Med. Ass. 1913.) 



3 ) Verploegh, H., Kehrer, J. K. W. en van Hoogenhuyse, C. J. C, 

 Bacteriologisch Onderzoek bij Lymphogranuloma. (Ned. Tijdschr. v. Gen. II A 

 N°. 2, 1914). 



4 ) Bunting, C. H. and Yates, J. L., An Etiologic Study of Hodgkin's 

 Disease. (The Journ. of the Am. Med. Ass., Vol. LXI, 1913.) 



6 ) Id., id., An Etiologic Study of Hodgkin's Disease. (The Journ. of the Am. 

 Med. Ass. Vol. LXII, 19 14.) 



