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whose textbook I cite this, is of opinion that we here have a 

 case of specific attraction between tubercle-baccilli and those 

 organs. SCHUM 1 1) succeeded in demonstrating in septic thromboses 

 an active excretion and exsudation of the vascular wall. He 

 describes pseudo-membranes on the endothelial cells which 

 apparently had their origin from those cells. In sections through 

 septic organs the quantity of chromocytes lying outside the 

 vessels often attracts the attention. This too proves a lesion 

 of the endothelium of the smaller vessels. OTTO 12) only recently 

 pronounced this view with regard to typhus exanthematicus. 

 FRÄNKEL 13) too discovered endothelial changes in typhus exan- 

 thematicus. Others are of opinion that the epithelioid cells which 

 contribute to the formation of tubercles originate from the 

 endothelia. 5) 



In chronic infections we find amyloid. This too is, at least 

 where it is met with in capillaries, an unmistakable product of 

 endothelial cells. 14) 15) After VAN ERMENGHEM 16) the endothelia 

 in botulismus are degenerated. 



In this connection possibly attention might be called to the 

 fact that infectious diseases favour the development of athero- 

 matic processes in the arteries 17) 



Here a digression seems necessary. Acute lymphagitis after 

 HERXHEIMER 8) consists anatomically of swelling of the endothelial 

 cells of the intima, and desquamation of the same ; later on 

 lymphthrombi arrive on the scene. This is a parallel process 

 with what happens in bloodvessels. 



We may expect that the spleen, endowed with its rich and 

 peculiar endothelium, will show a particularly strong reaction 

 in septic conditions : the enlargement of the spleen, clinically 

 so well known, is to a great extent the consequence of the 

 increase in number and size exhibited by the sinusendothelial 

 cells, and there bacteria are found very easily. HERXHEIMER 8) 

 himself accentuates this: '"Besonders zeigen sich auch die 

 sichelförmigen Endothelien in grosser Zahl und zu erheblichem 

 Umfang angeschwollen." 



There exist therefore in pathological and in clinical respect 

 many reasons why we may localise the condition which is com- 

 monly called septicaemia in the endothelial cells. 



The collargoltherapy has booked many successes in conditions 



