34 FLORA HOMGOPATHICA. 
1000 drops of alcohol, at a low temperature, and the tincture 
so obtained to be applied to make the different attenuations as 
ordered in the preparation of other medicines. Dr. Quin 
(Pharmacop. Homeop., p. 41) advises the tincture prepared after 
this manner to be left at rest for six days, and that the attenua- 
tions should only go as far as the ninth. Jahr (Pharmacopeia and 
Posology, American translation, p. 129) advises the three first 
attenuations to be prepared by trituration, rather than by diges- 
tion with twenty parts of alcohol, which should be done if 
we wish to preserve it under the form of tincture.* 
Poisonous Errrcrs.—Hahnemann has the following remarks 
upon the effects of an over dose of the medicine prepared from 
this bark. ‘“ The true bark, as described above, possesses also 
most powerful medicinal properties, so that when obtained fresh 
from the tree, as it now generally is, it may, like all other 
highly powerful drugs, cause serious consequences, when 
it has been administered inappropriately and in over large 
quantities. A child, six and a half years old, who had been 
given three teaspoonfuls of a decoction of Angustura, made of 
five ounces of bark, reduced by evaporation to five ounces of 
liquid, ¢. e. about an ounce and a half of the extract of Angus- 
tura, died in two hours under the following alarming symptoms, 
taken from the report of Emmert. Tremblings, becoming 
violent in about half an hour; tetanic convulsions on touching 
the arm; eyelids wide open; eyes fixed, starting, and immov- 
* The mode of preparation by trituration is as follows : one grain of the medicinal 
_ Substance, say the bark, is added to ninety-nine grains of sugar of milk, this is rubbed 
ina porcelain mortar for six minutes, and then is designated the first attenua- 
tion; to make the second, one grain of the first is mixed with ninety-nine grains 
of sugar of milk, and submitted to the same process; and the third attenuation is 
made in the same manner, by taking one grain of the second ; to make the fourth, 
one grain of the third is dissolved in a bottle filled with 100 drops of water to two- 
thirds its capacity, and this mixture is shaken twice, as in the attenuations made 
with alcohol. The fourth attenuation is best made with water, or equal parts of 
water and alcohol, because the sugar of milk does not dissolve in pure alcohol, but 
all the following attennations after the fourth are to be made with pure spirit. 
