ANGUSTURA. 35 
able; the jaws fixed; the lips wide apart, showing the whole 
of the front teeth; tension of some of the muscles of the face ; 
the limbs fully extended and stiff; the spine and head thrown 
violently back; the body from time to time was shaken and 
slightly raised by a violent shock, like an electric shock, along 
the back; the cheeks and lips became blue; the breathing 
interrupted. After an access of six minutes, the child breathed 
with much effort, the cheeks and lips becoming pale. There 
was frequent desire to drink coffee. Swallowing tepid water 
caused tetanic spasms. Pulse 200, spasmodic and irregular. 
The tetanus sometimes appeared of its own accord, at others, 
from noise or from contact with anything; and the child con- 
tinually cried out from fear of being touched. After the 
tetanus the eyes were closed; the face and forehead covered 
with perspiration; cheeks and lips blue; moaning, apparently 
without pain. The whole body flexible and soft; the eyes 
glazed, with convulsive breathings at long intervals. Half an 
hour after death the body became stiff. After twenty-four 
hours, on opening the veins, the blood was found liquid and 
brownish; the right lung pale and emphysematous externally, 
full of blood internally. The left was blue externally, blackish 
at the division of the lobes, and very full of blood. Other facts 
also prove that too powerful doses of Angustura produce 
spasmodic convulsions, giddiness, anxiety, and loss of con- 
sciousness. Dr. Wuerzner informed me that four persons, each 
of whom took ten or twelve grains of the extract of Angustura 
in the form of pills, were seized with stiffness, somewhat analo- 
gous to tetanus, in all the muscles of the body, with tremors 
of the jaws, and fell suddenly to the ground without losing 
consciousness.” Symptoms much resembling these, only much 
less powerful, are related in the provings of this medicine on 
persons in health ; viz., Sensation of weakness and stiffness of the 
whole body. Stiffness and extension of the limbs. Tension in the 
muscles whilst walking. Sensation of paralysis of different parts. 
Convulsive starts. Attacks of spasms, excited mostly by the 
