155-3 
of extremely bitter taste, soluble in water; in this view he was corroborated by 
Etti.* Bungener,+ however, disclaims the solubility and purity of the product on 
account of the potash used in its isolation, and describes the body as follows: Hop 
Litter Acid, C,,H,,0,. This “acid aldehyde” results in beautiful prismatic crystals, 
melting at 92°-93° (197.6°-199.4° F.), soluble in alcohol and chloroform, not sol- 
uble in water, and having a bitter, acid taste. On exposure to air it turns yellow 
and oxidizes like the oil, forming valerianic acid in part. 
[Lupuline.—This body, claimed as a liquid, volatile alkaloid, having the odor 
of Conia, was isolated by Griessmayer;{ no other analyst seems to have met with 
the product. ]} 
Choline, C,H,,NO,.—This principle, found in the bile, brain, and yolk of eggs, 
was discovered in the hop by Griessmayer and Harrow.§ 
Trimethylamine, C,H,N.—This nitrogen base of methyl was discovered in 
the hop by Griessmayer. It boils at + 9.3° (+ 48.5° F.), has a nauseous odor, 
resembling that of herring brine, in which in fact it is found, and is soluble in 
water and in alcohol.|| 
Humulo-Tannic Acid,§ C,,H,,O,,.—This body forms in a whitish amorphous 
mass, soluble in water and alcohol, but not possessing the power—general in 
tannic acids—of precipitating gelatine; however, on heating the mass at 130° 
(266° F.), it parts with one molecule of water, and is transposed as follows: 
Humulo-Tannic Acid, Water. Phlobaphine. 
(CFO. — H,O + oe 3 AB 
This phlobaphine results in a red amorphous substance which readily precipitates 
gelatine.** 
Oil of Humulus, C,,H,,+ C,,H,,O (Wittstein)—This oil, obtained from the 
strobiles, results as a greenish- or reddish-brown body, according to the ripeness 
of the cones. It is thin, neutral, hot tasting, and slightly bitter, has a density of 
0.910, distills at 125°-175° (257°-347° F.), and hydrates at 210° (410° of Rae +: 
resinifies when exposed to the air, and develops valerianol (C,H,,O), which after- 
ward passes into 
Valerianic Acid, C,H,,O,—This body, obtained from the roots of Vaderiana 
officinalis, was determined by Méhu++ to also exist in Lupulin in the proportion 
* Am. Four. Phar., 1879, 27; from Four. Chem. Socy., 1878: from Ding. Polyt. —_— 227, PP- 354-7- 
+ Am, Four. Phar., 1884, p. 427; from Phar. Four. and Trans., 1884, 1008. 
t Am, Four. Phar., 1874, 360. 
4 Chem. News, 1885, 149. 
|| Griessmayer, 747d, 
{ Lupulo-Tannic Acid; but this name is not appropriate, as Dr. ‘icin appears to prove that there is no tannin 
in Lupulin, unless some other portion of the hop dusts into this product. 
** Etti, 1826-8, and Am. Your. Phar., 1879, 27; before quoted. 
+F Thesé, —— 7, in Fliick. and Han., Pharmacographia. 
