BY C. J. MAirnX AND FRAXK TIDSWELL. 491 



results of which were sufficiently definite. Rabbits were chosen 

 for the purpose, on account of their suitable size. 



The following are the details : — 



Experimeid I : On June 18th, 1894, a healthy rabbit of average 

 size and in a very lively condition had 'OS gramme of the poison 

 dissolved in 5 cc. of 75% salt solution injected under the skin of 

 the abdomen at 2 p.m. Its temperature at the time was 102° F. 

 During the injection the animal sti-uggled, and afterwards remained 

 much quieter. For the rest of the day the animal remained 

 very quiet in its cage, but no local signs were observed. 



June 19th. A swelling about the size of a duck's egg has 

 appeared near the seat of injection. This swelling has a semi- 

 cystic feel, is not circumscribed, is movable over subjacent tissues, 

 but adherent to skin. It is tender to the touch. The animal is 

 sick — it does not struggle nor attempt to escape when handled, 

 its eye is dull, and it eats only sparingly. Temperature 102-8° F. 

 A specimen of blood removed from the ear clotted readily in a few 

 minutes, and was normal in microscopic appearance. At 6 p.m. 

 the same day the swelling had slightly increased, extending up- 

 wards over thorax. The animal has been quiet all day, remaining 

 huddled up in a corner of its cage, and passively submitting to 

 handling. Tempera.ture 103-1° F. 



June 20th. The swelling is much smaller and is less tender. 

 The animal is much livelier, has taken more food. Temperature 

 102-8° F. 



June 21st. The swelling has almost disappeared. The animal 

 is very lively, taking food well, and struggling when handled. 

 Temperature 102-6° F. 



June 22nd. The swelling has quite disappeared ; the eye is 

 bright and the animal apparently quite recovered. The seat of 

 injection has a bruised appearance, but is not tender to the touch. 

 After this no further symptoms appeared ; the animal recovered 

 completely from its illness in five or six days after the injection. 

 It is at the present time (July 28th) alive and well. 



