96 PHYSIOLOGY OF THE PANCREAS, 



the secretion of pancreatic juice through pilocarpine, and if 

 administered previously prevents the commencement. 



Protocols of an experiment, Oct. 4th. — 20 c.c. of *25 % pilocarpine were 

 injected into the jugular vein of a dog weighing 12 kgms. Three minutes 

 after drops of juice fell at intervals of forty seconds for five minutes, when 

 15 c.c. of "25% atropine were injected. In three minutes secretion stopped. 

 After twelve minutes 20 c.c. of pilocarpine solution "25% were injected into 

 the vein. No secretion resulted from the pancreas, although secretion was 

 very rapid from the salivary glands. Ten minutes later 16 c.c. of secretin 

 were injected, and after 105 seconds secretion at five drops a minute started. 



Pancreatic secretion evoked by secretin seems independent of 

 the blood pressure. It occurs with considerable vigour even when 

 the blood pressure is lowered greatly by the depressor substance 

 in the intestinal extract or by toxic atropine doses. 



Protocol of an experiment, Sept. 14th. — There were injected 4 c.c. of an 

 extract from the tortoise {Chelodina lomikollis) into the jugular vein of a dog 

 weighing S kgms. After 90 seconds secretion at the rate of one drop in 40 

 seconds was established. Five minutes later 18 c.c. of 3 % atropine sulphate 

 solution were injected into the vein. The blood pressure fell within one 

 minute to 5 mm. Hg., but secretion continued for nine minutes, at the rate of 

 about one drop a minute, when the experiment ceased. 



The pressure under which the juice was excreted was measured 

 by allowing the juice to flow up a vertical tube. The fluid was 

 raised 8| inches and 9 inches on two occasions The same 

 heights were observed by filling the vertical tube to a greater 

 height when the pressure fell to the same height as when the 

 fluid flowed up the tube. These two methods were used in each 

 case. The juice flowed up the tube until it remained constant. 

 The tube was connected to the canula by a piece of rubber 

 tubing. This allowed the vertical tube to be then raised. The 

 juice then ran back until the height before observed was obtained. 

 The flow of juice was very active on opening a tube connected 

 with the canula and clamping the vertical tube, showing that 

 active secretion was in progress. This pressure is much less than 

 that in the arteries, the lower pressure in the carotid artery in 

 my observations being 35 inches of blood (calculated from mer- 

 curial manometer). A like pressure was observed in the pan- 



