12 CONTENTS 



X-ray analysis of haemoglobin 



M. F. Perutz page 136 



Further study on myoglobin: I. Heterogeneity of human myo- 

 globin. Some properties of Mb I and Mb II 

 A. Rossi-Fanelli and E. Antonini 140 



II. Chemical and Biochemical properties of a new type of myo- 

 globin in molluscs 



A. Rossi-Fanelli, E. Antonini and D. Povoledo 144 



The chemical effects of gene mutations in some abnormal human 



haemoglobins 



J. A. Hunt and V. M. Ingram 148 



Proteolytic Enzymes 



10 Etude de quelques proteolyses limitées du chymotrypsinogène de 

 bœuf 



P. Desnuelle et M. Rovery 1 55 



Studies on the autocatalytic activation of trypsinogen 



J. F. Pechère and Hans Neurath 1 69 



Comments on the structure of a-chymotrypsin 



B. S. Hartley 175 



Reaction of trypsin with organophosphorus esters 



T. Viswanatha 176 



Modification of pepsin by autodigestion 



Gertrude E. Perlmann and Mary J. Mycek 1 79 



1 1 Some studies on the structure and activity of papain 



Emil L. Smith, Robert L. Hill and J. R. Kimmel 1 82 



Ribonuclease 



12 Studies on the structure of ribonuclease 



C. H. W. Hirs, William H. Stein and Stanford Moore 21 1 



13 The structure of ribonuclease in relation to its enzymatic activity 

 and physical properties 



C B. Anfinsen 223 



Immunological approaches to the study of ribonuclease 



B. Cinader and J. H. Pearce 240 



Tobacco Mosaic Virus 



14 Degradation and structure of tobacco mosaic virus 



H. Fraenkel-Conrat and K. Narita 249 



