Hb A 



Hb S 



kvvlQ^ 



C'VL-L 



•::V'T-p-v 



; ;tpv-c 



HV-L (9"^P-^ 



HVO (>-P-V-C-Ly 



- • -h 



8- 



i- 



o^ 



O 



■*— 

 o 

 E 

 O 



F/g. 1 (a). Acid Degradation of the No. 4 Peptides from Haemoglobins A and S. 



+ + - - +- 



Hb A . . His-Vql-Leu-Leu-Thr-Pro-Glu.-Glu-Lys 



t 



f 



+ + _ +- 



HbS .. ^His-Val-Leu-Leu-Thr-Pro-Voi-Glu-Lys 



T 



f 



+ + ^ ■♦■- +- +- 

 HbC .... His-Val-Leu-Leu-Thr-Pro-Lvs^Glu-Lys. 



= t t t 



Fig. 1 {b). Structure of the No. 4 Peptides from Haemoglobins A, S and C. 

 (H = His=histidine, V= Val = valine, L= Leu = leucine, T=Thr= threonine, P=Pro= 

 proline, G = Glu = glutamic acid, Ly = Lys = lysine.) 



