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INDEX 



347 



Fibrinogen, viscosity, 38 

 Fibroin, a-helix in, 17 



antibodies to, 291 

 Fluorescence, polarization of, 54, 59 



Gliadin, dialysis rate, 108 

 y-Globulin 



optical rotation, 57-58 

 viscosity, 57-58 

 Glucagon, dialysis rate, 108 

 Glutamine, localization in peptides, 



192, 218-219 

 Growth hormone 

 enzymic modification and activity 

 chymotrypsin, 318-319, 322, 324, 



326 

 carboxypeptidase, 318, 322 

 LiAlHi reduction, 330-332 

 physico-chemical properties, 318, 



321, 325 

 purification, 320 

 species differences, 318-327 

 Guanidine-acetate ion interaction, 



42-43 

 Guanidine hydrochloride, 219, 236, 

 251 



Haemoglobin 

 basic peptides from, 87-89 

 C, 150-151 

 configuration, pH dependence of, 



54-55 

 denaluration, 44, 55 

 dissociation, 61, 89 

 haem groups, orientation of, 139 

 peptides from tryptic hydrolysates, 



148-151 

 genetic control of structure of, 



148-151 

 shape of molecule, 137 

 sickle cell, 17-18, 74, 148-151 

 sulphydryl groups, 136-138 

 X-ray analysis, 136-139 

 Haptenes, 293-294 

 a-Helix 

 in polypeptides, 17, 24, 28-29, 31- 



33, 36 

 in proteins, 17, 32, 36-38, 136, 



172-173 

 Histidine 

 in active centre of chymotrypsin, 



175 



cytochrome C, 72 

 myoglobin, 145 

 trypsin, 172-173, 175 

 and organophosphorus ester 

 hydrolysis, 177 

 Hydrazides, chromatography of, 259 

 Hydrazinolysis, 171, 215, 218, 258- 



260, 264, 267, 310, 315, 317 

 Hydrogen bonds 

 between peptide groups, 17-34, 41, 

 42, 47 (see also a-helix and 

 deuterium exchange) 

 breakage mechanism, 28, 29, 32 

 linearity of, 19-21 

 carboxyl-carboxyl, 41, 42 

 carboxyl-guanidine, 42-43 

 carboxyl-tyrosine, 41, 42 (see also 

 Tyrosine, ionization of) 

 in pepsin, 179 

 in ribonuclease, 236-238 

 in tobacco mosaic virus, 252-255 

 in serum albumin, 53-54 

 and sulphydryl groups, 252 

 in trypsin, 173 

 in urea solutions, 41 

 in water, 39, 41 

 Hydrophobic bonds, 33, 39, 47, 49 

 Hydroxy lamine, 

 reaction with organophosphorus 

 esters, 177 

 tobacco mosaic virus, 266 

 Hypertensin, species differences, 73 



Insulin 



A chain, deuterium exchange, 32 



dialysis rate, 111, 112 

 B chain, a-helix, 17 



dialysis rate, 108, 112 

 configuration in solution, 59 

 deuterium exchange, 32 

 polymerization, 60, 111 

 species differences, 73 

 zinc, role in crystallization of, 341- 

 343 

 Intermedin, see Melanotropin 

 Ionization of groups in proteins, 43-62, 



201-203, 236, 252-254 

 Isotope dilution, amino acid estimation 

 by, 116-121 



Kinetics 

 of deuterium exchange, 23-34 

 of papain action, 200-203 



