350 



INDEX 



Rîbonuclease — cont. 

 inhibition by alkaline pH, 236 

 antibodies, 244, 246 

 esterification, 236 

 guanidine salts, 236, 237 

 oxidation, 236, 238 

 pepsin digestion, 233, 235, 238 

 reduction, 230-232 

 optical rotation, 234, 235 

 oxidized, deuterium exchange, 32 

 dialysis rate, 108, 1 10 

 enzymic hydrolysis of, 211-215, 

 219, 227 

 reduced and carboxymethylated, 

 225-227, 230-232 

 enzymic hydrolysis of, 227, 232 

 viscosity, 38, 49, 58, 60, 234-235 

 Ribonucleic acid, 234, 250, 256, 262, 

 272 



^Salt links' in proteins, 42-43 

 Sedimentation coefficients, see under 

 individual proteins, physico- 

 chemical properties 

 Serum albumin 

 amino acid composition, 292 

 species variations in, 73, 79 

 configuration and pH, 52-54 

 diffusion constant, 52 

 disulphide bonds, 45, 62 

 immunologically active fragment 

 of, 290-294 

 amino acid composition, 292 

 dimerization, 291-293 

 physico-chemical properties, 



291-292 

 stabiUty, 293 

 polymerization, 62 

 sedimentation constant, 52 

 tyrosine ionization in, 53 

 viscosity, 38, 52 

 Serum proteins 

 in amphibian metamorphosis, 296- 



297 

 as iso-antigens, 298-301 

 Subtilisin 

 action on DNP-tobacco mosaic 

 virus protein, 268 

 ribonuclease, 229, 231-233, 236 

 Sulphydryl groups 

 in haemoglobin, 136 

 in papain, 184-186, 202-206 



reaction with p-chloromercuriben- 

 zoate, 130, 136, 184-186,205 



iodine, 252 



iodoacetamide, 185, 186, 316 



iodoacetate, 224-232 



methyl mercury, 252 

 in serum albumin, 292-293 

 in tobacco mosaic virus, 251-252 



Titration curves, see Ionization 

 Tobacco mosaic virus 

 hydroxylamine, reaction with, 266 

 metal ion binding by, 255-256 

 peptides from proteolysis of, 256- 



260, 267-269 

 protein subunits, 249-251, 263, 

 271-273 

 bonding of, 253-256 

 molecular weight of, 250-251, 

 267-269 

 stability, 250-251, 256, 263 

 strains, differences between, 73, 



247, 262-263 

 sulphydryl groups, 251-252 

 trichloroacetic acid on, 266, 269 

 X-ray analysis, 271-273 

 Trypsin 

 action on carbobenzoxylated pro- 

 teins, 224, 227-228 

 chymotrypsinogen, 155-159, 



162-163 

 corticotropin, 310-311 

 enolase, 338-339 

 lysozyme, 227-228, 280-285, 289 

 melanotropin, 305, 333-334 

 papain, oxidized, 188-192 

 ribonuclease, 211-221, 227 

 tobacco mosaic virus, 257 

 trypsinogen, 169-173 

 dialysis rate, 108, 110 

 reaction with organophosphorus 

 esters, 

 effect of acetylation on, 177 

 effect of urea on, 176-178 

 specificity of, 288-289 

 C-terminal configuration, 171 

 Trypsinogen 

 activation of, 169-174 

 acetyl derivatives of, 171 

 effect of urea on, 173 

 amino acid composition, 81 

 basic peptides from, 85-87 



