72 ANTIBIOTIC ACTION OF ANTAGONISTS 



TABLE 9. BACTERIOSTATIC SPECTRUM OF PENICILLIN 



DILUTIONS AT WHICH INHIBITORY 



ORGANISM AFFECTED EFFECTS WERE OBSERVED 



Complete Partial None 



l^l . gonorrhoeae* 2,000,000 >2,000,000 )>2,ooo,ooo 



N . meningitidis 1, 000,000 2,000,000 4,000,000 



S. aureus 1,000,000 2,000,000 4,000,000 



S. -pyogenes 1,000,000 2,000,000 4,000,000 



B.anthracis 1,000,000 2,000,000 4,000,000 



A.bovis 1,000,000 2,000,000 4,000,000 



CI. tetaniif i ,000,000 



CI. zoelchii 1,500,000 



CL sefticum 300,000 1,500,000 7,500,000 



Cl.oedematiens 300,000 1,500,000 



5. viridans% 625,000 3,125,000 



Pneumococcus\ 250,000 500,000 1,000,000 



C. difhtheriae {mitis) 125,000 625,000 



C. difhtheriae {graz'is) 32,000 64,000 128,000 



5". gartneri 20,000 40,000 8o,000 



S.tyfhi 10,000 30,000 90,000 



PneumococcusX 9,000 27,000 



Anaerobic streptococcuslj! 4,000 8,000 16,000 



P. vulgaris 4,000 32,000 60,000 



S.viridansX 4,000 8,000 16,000 



P.festis 1,000 100,000 500,000 



S. tyfhimurium < 1,000 8,000 16,000 



5. faratyfhi B < i ,000 5 ,000 I o,000 



5^. dysenteriae 2,000 4,000 8,000 



Br. abortus 2,000 4,000 8,000 



Br. melitensis <i,000 2,500 I0,000 



Anaerobic streptococcus <^4,ooo <(4,ooo 4,000 



V. comma < 1,000 1,000 2,000 



E.coli <i,ooo <i,ooo 1,000 



K. fneuTnoniae <( i ,000 <^ i ,000 i ,000 



Ps. aeruginosa <^ i ,000 < i ,000 i ,000 



M. tuberculosis ^ i ,000 < i ,000 1 ,000 



L. icterohoemorrhagioe < 3,600 <( 3,600 3j6oo 



From Abraham et al. (7). 



* Another strain was inhibited only up to 32,000. 



t Grown in Lemco broth; in beef broth complete inhibition reached only 100,000. 



X In Pneumococcus, S. viridans, and anaerobic streptococci, different strains appear at different 



levels in the table. 



