164 CHEMICAL NATURE OF ANTIBIOTIC SUBSTANCES 



at 100° C. but was weakened at 1 15° C. for 10 minutes. It is considered 

 similar in its bactericidal properties to pyocyanase. 



Alcohol and acetone extracted from B. mesenterkus a weakly active 

 substance (408) that diffused through a cellophane membrane and 

 could be partly absorbed on a Berkfeld filter. When shaken directly 

 with ether, the culture lost its antibacterial properties. The ether extract 

 was concentrated and ammonia added, and the solution was treated with 

 50 per cent alcohol. The alcohol was then removed, and the residue was 



1 ! ! 



c c c 



CH,O.C C=CH2 H2C C=CH\ HOC CH H3CI 



II I I I > II II , 



HC CH3 H2C CH.CO/ HC C.CH2OH li yOCHj 



I V V „ 



O 



COOH 

 PENICILLIC ACID 



CLAVACIN 



KOJIC ACID 



H3C 



PYOCYANIN 



PHENAZINE 



FUMIGATIN 



CONH2 



CHLORORAPHIN 



Figure i6. Structural formulae of some antibiotic substances. 



