180 



CHEMICAL NATURE OF ANTIBIOTIC SUBSTANCES 



TABLE 34. NATURE OF SECOND ANTIBIOTIC FACTOR PRODUCED BY 

 PENICILLIUM NOTATUM 



Ox\-gen required 

 for activity 



Activity against 

 gram-negative 

 bacteria in addi- 

 tion to gram- 

 positive bacteria 



Sensitivity to alka- 

 lies 



Biological nature 



Apparently required Required 



Required 



Decidedlv active 



Sensitive 



Hydrogen peroxide 

 produced; not 

 verv toxic 



Highly active Definitely active 



Activity de- 

 stroyed at />H 

 above 8.0 



Glucose-oxidase 



Fairly toxic to 

 animals 



Note. In view of the fact that the three preparations have been obtained by somewhat diflFerent 

 chemical procedures and in view of the variation of the strains of P. notatum producing this sub- 

 stance, there is a possibility that the different preparations may vary in chemical nature and pos- 

 sibly also in biological behavior. 



