244 



DISEASE CONTROL 



Virulent strains of M. tuberculosis were found to lose their virulence 

 in the presence of certain other organisms or their products. According 

 to Vaudremer (912), this phenomenon occurs when the tubercle or- 

 ganism is kept for 24 hours at 39° C. in contact with a filtered extract 

 oi A. jumigatusy and a similar effect can be exerted by certain bacteria 

 (708). On the other hand, extracts of A. jumigatus were used for the 

 treatment of 200 tubercular patients with rather inconclusive results 

 (912). 



TABLE 45. IN VIVO EFFICACY OF STREPTOTHRICIN COMPARED WITH 

 SULFADIAZINE IN SALMONELLA AERTRYCKE INFECTION IN MICE 



From Robinson (752). 



* 0.5 cc. of a 6-hour-olcl culture dilution in broth. 



t Streptothricin given subcutaneously immediately after inoculation of bacteria. 



Treatments of intestinal disturbances by the use of antagonistic micro- 

 organisms, although highly promising, have not been sufficiently in- 

 vestigated as yet. It may be of interest to note, in this connection, that 

 the presence in human intestines of E. coU with a high antagonistic in- 

 dex is considered as important evidence of immunity of certain indi- 

 viduals to intestinal disturbances (383, 580, 619, 643). 



