CONTENTS 



Biographical Introduction vii 



Introductory Editorial Note xi 



I. General Considerations of Lipid Digestion, Absorption, Transport, 



and Storage 1 



1. Introduction 1 



2. The Digestion and Absorption of Triglycerides, Phospholipids, and 



Fatty Acids in the Gastrointestinal Tract 2 



3. The Role of the Lymph and Blood in the Transport of Triglycerides, 



Phosphohpids, and Fatty Acids 3 



4. The Deposition of Triglycerides and Phospholipids in the Tissues 5 



5. The Absorption, Transport, and Storage of Cerebrosides and Hydro- 



carbons 6 



II. The Biosynthesis of Triglycerides, Phospholipids, and Fatty Acids 



in the Animal Body 9 



1. Introduction 9 



2. The Biosynthesis of Saturated Fatty Acids 10 



(1) Possible Building Stones of Fatty Acids 10 



a. Acetaldehyde as the Two-Carbon Fragment Required for Fatty 



Acid Synthesis 10 



b. Ethanol as the Two-Carbon Fragment Required for Fatty 



Acid Synthesis 11 



c. Acetate as the Two-Carbon Fragment Required for Fattj' Acid 



Sjmthesis 11 



(a) Acetylphosphate as the Possible Precursor 14 



(b) Coenzyme A and "Active Acetate" 14 



(2) The Site of Bios3'nthesis of Fatty Acids from Acetate 17 



(3) The Mechanism of Sj-nthesis of Fatty Acids from Acetate 20 



a. The S3'nthesis of Acetoacetate from Two-Carbon Fragments. 20 



b. The Synthesis of Long-Chain Fatty Acids from Acetate 23 



c. The Elongation of the Fatty Acid Chains with Acetate 25 



(4) The Role of Coenzj'me A in Fat Sj-nthesis 27 



a. Coenz3Tne A in the Transfer of Two-Carbon Intermediates. . 27 



(a) The Function of Phosphotransacetylase 29 



(b) The Role of the Condensing Enzyme 29 



b. The Mechanism of Transfer of Acj-1 Groups by Coenzyme A . 29 



c. The Chemical Nature of Coenzyme A 30 



(a) Different Natiu-al Forms of Coenzj^me A 31 



d. Reactions of the Thiol Group of Coenzyme A 32 



e. The Distribution of Coenzyme A 32 



(5) The Role of Enzj^mes in the Biosjm thesis of Fat 33 



xiii 



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