CONTENTS Xvii 



III. The Oxidation and Metabolism of Triglycerides, Fatty Acids, and 

 Glycerol in the Animal Body (continued) 



(g) Experimental Ketonuria in Rats 143 



a'. Exogenous Ketonuria 144 



b'. Endogenous Ketonuria 145 



d. I'^actors Altering the Extent of Ketonuria 146 



(a) Species as a Factor in Ketonuria 146 



a'. Ketosis in Cattle 147 



b'. Ketosis in Sheep 150 



c'. Ketosis in Goats 152 



d'. Ketosis in Hogs 152 



e'. Ketosis in Fowls 153 



f . Ketosis in Miscellaneous Animals 153 



(b) Age as a Factor in Ketonuria 154 



(c) Sex as a Factor in Ketonuria 155 



(d) Type of Food Ingested as a Factor in Ketonuria 157 



(e) Adaptation as a Factor in Ketonuria 158 



(f) Hormones as Related to Ketonuria 160 



e. The Mechanism of the Effect of Carbohydrate on Ketonuria . . 163 



(a) Theories to Explain the Mechanism of the Action of Carbo- 



hydrate on Ketosis 164 



(b) Experimental Evidence Concerning the Mechanism of the 



Action of Carbohydrate on Ketonuria 165 



a'. In Vitro Analogy of Coupled Reactions 165 



b'. The Tricarboxylic Acid Cj^cle and the Oxidation of 



Ketone Bodies 166 



c'. The Specific Effect of Glucose and of Glucose Pre- 

 cursors on Ketonuria 172 



d'. The Negative Effect of Non-Glucose Precursors on 



Ketonuria 174 



e'. The Effect of Glucose on the Exogenous Ketonuria of 



Rats 175 



f '. The Effect of Glucose on the Rate of Disappearance of 



Ketone Bodies in the Intact Animal 177 



g'. The Effect of Glucose on the Rate of Disappearance of 



Ketone Bodies in Liver Slices in vitro 177 



(c) Resinne of the Mechanism of Action of Carbohydrate on 



Ketonuria 179 



f . The Comparative Ketolytic Effect of the Sugars 180 



g. The Metabolism of Acetone 181 



(5) The Metabolism of Polyunsaturated Acids 183 



a. Interconversions of Linoleic Acid 183 



(a) Conversion of Arachidonic Acid 183 



(b) Transformation to Polyimsaturated Acids Other Than 



Arachidonic Acid 185 



b. Interconversions of Linolenic Acid 185 



c. Interconversions of Elaeostearic Acid. . . . -x<^ip^r>>^ 187 





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