342 



VII. ACIDS, AMIDES. ALDEHYDES AND HYDROCARBONS 



The MetaboUsm of Pseudocumene in the Dog^" 



Only xylic acid has been reported as the excretion product after the 

 feeding of 1,2,4-trimethylbenzene {psevdocumene) . In sharp contrast to 

 this, when the isomeric 1,3,5-trimethylbenzene (mesitylene) is oxidized by 

 the dog and rabbit, both the acid^^''-^'^ ^j^^j ^j^g phenoHc derivative^'' 

 originate. 



CHsks^ i^CHj 

 Mesitylene 



CHalxiiCOOH 

 Mesitylenic acid 



CHak ]iCO • NH • CH2COOH 

 Mesitylenuric acid 



CHs^ iiCHs 

 Mesitol 



CH 



COOH 



p-Hydroxymesitylenic 

 acid 



The Metabolism of Mesitylene in the Dog, Rabbit, and Pigi7o.23o,232.233 



According to von Nencki'^'^ ^j^^ Fihppi,^'^ mesitylenic acid is excreted 

 both in the free form and combined with glycine. 



"1 O. Jacobsen, Ber., 12, 1512-1518 (1879). 



^'^ L. von Nencki, Naunyn-Schmiedeberg's Arch, exptl. Pathol. PharmakoL, 1, 420-425 

 (1873). 



*'' A. Curci, Jahresber. Tierchem., 24, 100 (1894); cited by R. T. WilUams, Detoxication 

 Mechanisms, Wiley, New York, 1949, p. 42. 



