1004 



SUBJECT INDEX 



Acetate {continued): 



effect of thyroid, 37 



protoporphyrin from, 270, 271, 279 



sphingosine from, 67 



squalene from, 323, 324, 384, 388 



succinate from, 272 



uric acid from, 261, 279 



vs. p3'ruvate, 138, 261 

 Acetate-activating enzyme, 108 

 Acetic acid (see also Acetate) 



absence from tissues, 81-83, 255-256 



antibacterial action, 866 



carbohydrates from, 215-217, 269 



from pyruvate, 136-138, 259-261 



functions, 253-279 



in amino acid metabolism, 264, 265, 279 



in rabbit hver, 25 



ketone bodies from, 78, 126, 129 



occiu-rence, 254-257 



oxidation, 79, 80 



sources, 257-262 

 Acetic anhydride, as "active acetate," 14 

 Acetin fats, 928 

 Acetoacetate, acetone from, 181, 182 



carbons in Krebs cjcle, 168 



cholesterol from, 383 



citrate from, 274-278 



CoA in S3^nthesis of, 15, 28, 33 



CO2 incorporation into, 133 



combination with oxaloacetate, 166, 

 167, 171, 172 



effect on hyperglycemia, 78, 218 



from acetate. 83-87, 125, 126, 164, 179, 

 279 



from acetopyruvate, 273 



from butyrate, 75 



from /S-hj'droxyisovaleric acid, 302 



from leucine, 133 



from long-chain acids, 81 



from odd-carbon acids, 129, 259 



from pyruvate, 136-138, 260, 261 



from triacetic acid, 304, 305 



from tyrosine, 136 



glucose and, 163, 164 



in acetylation, 265 



in blood, 154 



in fatty acid oxidation, 72, 74, 77, 102, 

 105, 110, 257 



Acetoacetate (continued) : 



in fatty acid sj'nthesis, 11, 23 



insulin, and, 161 



in unsaturated acids metabolism, 95, 

 96 



in urme, 121, 122, 154 



ketonuria from, 125, 144, 145, 176, 26S 



oxidation, extrahepatic, 198, 199 

 P:0 ratio during, 104 



reaction with glj^colaldehyde, 165 



synthesis of, 20-23, 37 

 Acetoacetyl-CoA, 107, 108, 109 

 Acetoglyceride, nutritional value, 927- 



931 

 Acetoin, 166 



cholesterol from, 387 

 Acetone, 120 



cholesterol from, 382, 383 



choline from, 287 



excretion, 77, 121, 122, 139, 141, 154 



formation in vitro, 75 



from muconic acid, 338 



in blood, 154 



metabolism, 181-183 

 Acetone bodies (see Ketone bodies) 

 Acetonic acid, 302 

 Acetonuria (see Ketonuria) 

 Acetooleins, absorption of, 930 



nutritional value, 930 

 Acetophenone, 74, 76, 77, 343 

 Acetopyruvic acid, 82-^3, 272-273 



metabohsm of, 304 

 Acetostearins, 927, 928 



absorption of, 930 



nutritional value, 930 

 3-j8-Acetoxy-17-Q;-hydroxy allopregnan - 



20-one (see Compound L) 

 Acetylase, 28 

 Acetylation, 28, 29, 262-267 



and origin of acetate, 258 



by pyruvate, 261 



choline, 267 



in the al>sence of free acetic acid, 14 



mercapturic acids, 266-267 



vs. detoxication, 262 

 A''-AcetyI-S-benzylcysteine, 346 

 Acetylcholine, 267 



oxidation in liver, 239 



