APPENDIX 



METHODS OF STUDY OF BACTERIAL 

 VIRUSES 



Mark H, Adams 



This article originally appeared in Volume 2 o^ Methods in Medical Research,* 

 which has been out of print for a number of years. We are greatly indebted 

 to the publisher and to the Governing Board of Methods in Medical Research 

 for the generous permission to reprint a slightly re-edited version of the article. 



We believe that the precision of bacterial virus experimentation, only scantily 

 described in most of the literature, and so well portrayed here, will be a valu- 

 able stimulus and pattern for the beginner, and for the worker in allied fields 

 of virology, interested in refining his experiments. The original article was, 

 we felt, so well designed by Mark Adams that we seriously contemplated re- 

 printing it without any revision. 



The decision to make some small revision was based upon the following 

 principles: The more or less theoretical material for an article intended to 

 stand by itself is not needed and is in some cases outdated by the text of the 

 present book. Such material, as well as an occasional bit of experimental 

 detail judged obsolete, is omitted in this reprinting, each place being indicated 

 by an appropriate ellipsis (...). When, after discussion with colleagues, it 

 was judged that omission of certain newer technical methods or details would 

 seem almost to misrepresent current practice, additions were made. These 

 were kept as few and small as seemed reasonable, and all but those of one or 

 two words are enclosed in brackets. 



The responsibility for oinissions or changes must rest with the undersigned, 

 but we wish to thank the many colleagues who off'ered advice, and in particular 

 Dr. George Streisinger, Dr. Norton Zinder, Dr. Margeris Jesaitis, and Professor 

 Max Delbruck. 



rollin d. hotchkiss 

 Nancy Collins Bruce 



January, 1958 



* Methods in Medical Research, Vol. 2, J. H. Comroe, ed., The Year Book Pub- 

 lishers; Inc., Chicago, 1950, pp. 1-73. Reprinted by pennission. 



443 



