Pfizer Handbook of Microbial Metabolites 



40 



57 Hygromycin A, C23H29O12N, amorphous (some crystalline deriva- 

 tives have been prepared), [aln"'^ —126° (c 1 in water). 

 Partial structure: 



HO- 



O 



1 

 HC- 



/ \— CH— C— C— NH 

 ^ CH3 



HOCH 



HCOH 



I 

 HC 



c=o 



CH3 



Streptomyces hygroscopicus (Jensen) Waksman and 

 Henrici 



R. L. Mann, R. M. Gale and F. R. Van Abeele, Antibiotics 

 and Chemotherapy 3 1279 (1953). (Isolation) 



Robert L. Mann and D. O. Wolf, J. Am. Chem. Soc. 79 120 

 (1957). (Structure) 



58 Homomycin, white powder, m.p. 105-109° (dec. >160°). 



Homomycin has been shown to be the same as hygro- 

 mycin except that the homomycin amino sugar moiety is : 



Streptomyces noboritoensis n. sp. 



Yusuke Sumiki, Gotaku Nakamura, Makoto Kawasaki, 

 Satoru Yamashita, Kentaro Anzai, Kiyoshi Isono, Yoshiko 

 Serizawa, Yoko Tomiyama and Saburo Suzuki, J. Antibiotics 

 (Japan) 8A 170 (1955). (Isolation) 



Mitsuo Namiki, Kiyoshi Isono, Kentaro Anzai and Saburo 

 Suzuki, ibid. lOA 36 (1957). (Structure) 



