Pfizer Handbook of Microbial Metabolites 42 



Also contains neamine. The disaccharide portion 

 (neobiosamine C) has been characterized, however, as: 



CH2NH2 



D-Ribose Neosamine C 



Streptomyces fradiae, other Streptomyces spp. 



Selman A. Waksman and Hubert A. Lechevalier, Science 

 109 305 (1949). (Isolation) 



Byron E. Leach, William H. DeVries, Harrison A. Nelson, 

 William G. Jackson and John S. Evans, J. Am. Chem. Soc. 73 

 2797 (1951). (Isolation) 



Jared H. Ford, Malcolm E. Bergy, A. A. Brooks, Edward R. 

 Garrett, Joseph Alberti, John R. Dyer and H. E. Carter, ibid. 

 77 5311 (1955). 



Kenneth L. Rinehart, Jr., Peter W. K. Woo, Alexander D. 

 Argoudelis and Astrea M. Giesbrecht, ibid. 79 4567 (1957). 



Kenneth L. Rinehart, Jr., Peter W. K. Woo and Alexander D. 

 Argoudelis, ibid. 79 4568 (1957). 



Idem., ibid. 80 6461 (1958). 



Kenneth L. Rinehart, Jr., and Peter W. K. Woo, ibid. 80 

 6463 (1958). (Structure) 



61 Catenulin (Sulfate) [a]ir^ +51.9° (c 1 in water). 



A substance resembling paromomycin. Acid hydrolysis 

 yields neamine.* 



Streptomyces catenulensis 



J. W. Davisson, I. A. Solomons and T. M. Lees, Antibiotics 

 and Chemotherapy 2 460 (1952). 



62 Dextromycin, Helianthate: m.p. 227°, Hydrochloride: [a]u'^ 



+61° (c 1 acetone). 



Similar to neomycin B.* 

 Streptomyces sp. resembling S. fradiae 

 Koichi Ogata and Koichi Nakazawa, J. Antibiotics (Japan) 

 3 440 (1950). 

 * Probably identical with paromomycin. (Private communication 

 from Drs. W. Celmer and C. Shaffner) 



