43 Alcohols, Glycols and Compounds Related to Sugars 



Toyonari Araki, Akira Miyake, Yoshitamo Aramaki, Hiroshi 

 Kojima, Hajime Yokotani, Koichi Ogata and Koichi Nakazawa, 

 Ann. Repts. Takeda Research Lab. 13 1 (1954). 



* Identical with neomycin B. See addendum. 



63 Framycetin (Actilin, Soframycin, Antibiotic E.F. 185), Hydro- 



chloride: white powder, [a]i. +57° (c 1.0 in water), m.p. 

 (picrate) 189° (dec). 



Framycetin resembles neomycin and streptomycin in 

 some respects, but is distinct. Hydrolysis yields neamine, 

 a pentose, and a diaminohexose. Framycetin forms pep- 

 tide derivatives such as a reineckate and a picrate. The 

 molecular weight is about 1400-1500. No guanidine 

 tests were observed, and all the nitrogen is present as pri- 

 mary amine groups. 



Streptomyces sp. resembling S. lavendulae 



Louis Jacques Decaris, Ann. pharm. frang. II 44 (1953). 



Maurice Marie Janot, Henry Penau, Digna van Stolk, Guy 

 Hagemann and Lucien Penasse, Bull. Soc. chim. France, 1458 

 (1954). 



A. Lutz and M. A. Witz, Compt. rend. soc. biol. 149 1467 

 (1955). 



A. Saito and C. P. Schaffner, Congr. intern, biochim.. 

 Resumes communs., 3"^ Congr., Brussels, 1955, p. 98. 



64 Hydroxymycin, probable empirical formula C._,r,H470i5N-,, white 



powder, [a]ir" 63° ± 2° (c. 1.0 in water) (Sulfate) white 

 powder, [aic-" +51° (c 1.0 in water). 



A basic antibiotic similar to streptomycin and neomy- 

 cin. Contains 6.2% total nitrogen and 6.0% amino nitro- 

 gen. It is water soluble and insoluble in most organic 

 solvents with a molecular weight of about 610. Hydroly- 

 sis yields a fragment called pseudoneamine and others 

 which show pentose and 2-aminohexose reactions. 



An antifungal substance was produced in the same 

 culture. 



Streptomyces paucisporogenes 



M. M. Janot, H. Penau, G. Hagemann, H. Velu, J. Teillon 

 and G. Bouet, Ann. pharm. frang. 12 440 (1954). 



G. Hagemann, G. Nomine and L. Penasse, Ann. pharm. 

 frang. 16 585 (1958). 



H. Penau, G. Hagemann and H. Velu, Bull. soc. chim. biol. 

 41 761 (1959). 



J. Bartos, Ann. pharm. frang. 16 596 (1958). 



