Pfizer Handbook of Microbial Metabolites 62 



Aspergillus spp., Piricularia oryzae ( biotin-deficient 

 medium) 



K. Ramachandran and V. Radha, Current Sci. (India) 24 

 50 (1955). 



Hirohiko Katsuki, /. Am. Chem. Soc. 77 4686 (1955). 



87 Otlier Keto-Acids: 



Many of the transitory a-keto-acids present in cultures 

 of microorganisms can be isolated by means of intercep- 

 tors such as 2,4-dinitrophenylhydrazine. One recent pa- 

 per reported the following acids identified principally in 

 lactic and propionic bacteria cultures: 



Glyoxylic Acid p-Hydroxyphenylpyruvic 

 Pyruvic Acid Acid 



a-Ketoisovaleric Acid Hydroxypyruvic Acid 



a-Ketoisocaproic Acid Oxalacetic Acid 



a-Ketocaproic Acid a-Ketoglutaric Acid 



Matti Kreula and Artturi I. Virtanen, Acta. Chem. Scand. 

 11 1431 (1957). 



88 Glutaric Acid, C,r,Hs04, colorless needles, m.p. Q?"". 



COOH 



I 

 CH2 



CH2 



I 



CH2 



COOH 



Aspergillus niger (on Z-xylose) 



Shinichiro Baba and Kinlchiro Sakaguchi, Bull. Agr. Chem. 

 Soc. (Japan) 18 93 (1942). 



89 Ita tartaric Acid, C^HgOfi, occurs as a gummy equilibrium mix- 



ture of lactone and free acid. Characterized as the methyl 

 ester derivative. 



COOH 



HO— C— CH,OH 



I 

 CHo 



I 

 COOH 



Aspergillus terreus mutant 



Frank H. Stodola, M. Friedkin, Andrew J. Moyer and 

 Robert D. Coghill, J. Biol. Chem. 161 739 (1945). 



