65 Aliphatic Acids and Glycolipides 



Yeasts (Isolated from Distillers' Dried Solubles). 



Donald E. Wolf, Carl H. Hoffman. Paul E. Aldrich, Helen R. 

 Skeggs, Lemuel D. Wright and Karl Folkers, J. Am. Chem. Soc. 

 78 4499 (1956). 



Helen R. Skeggs, Lemuel D. Wright, Emlen L. Cresson, 

 Gloria D. E. MacRae, Carl H. Hoffman, Donald E. Wolf and 

 Karl Folkers, /. Bad. 72 519 (1956). 



Carl H. Hoffman, Arthur F. Wagner, Andrew N. Wilson, 

 Edward Walton, Clifford H. Shunk, Donald E. Wolf, Fred- 

 erick W. Holly and Karl Folkers, /. Am. Chem. Soc. 79 2316 

 (1957). 



Clifford H. Shunk, Bruce O. Linn, Jesse W. Huff, James L. 

 Gilfillan, Helen R. Skeggs and Karl Folkers, ibid. 79 3294 

 (1957). 



97 x.^-Dihydroxy/S-methylvaleric Acid, C6H10O4, colorless syrup, 



[a]i,"' +3° (c 2.3 in water containing 1 equiv. of Ca(0H)2) 

 and -16.7° (c 2.3 in dilute HCl, pH 1 ). Forms crystalline 

 quinine salt. 



CH3 



CH3CH2— C— CH— COOH 



! ! 



OH OH 



A precursor of isoleucine isolated from a Neiirospora 

 crassa mutant. 



John R. Sjolander, Karl Folkers, Edward A. Adelberg and 

 E. L. Tatum, J. Am. Chem. Soc. 76 1085 (1954). 



98 2-Phospho-4-hydroxy-4-carboxyadipic Acid, C7H11O11P. 



OPO3H2 



HC— COOH 



I 

 CHo 



HO— C— COOH 



CH,— COOH 



Escherichia coli 



W. W. Umbreit, J. Bacteriol. 66 74 (1953). 



99 Lipoic Acid (6,8-Thioctic Acid), C8H14O0S2, pale yellow crystals, 



m.p. 47°, [7W +10.4°. 



CH2— CH2— CH— (CH,)4— COOH 



I I 



s s 



Yeast, E. coli mutant 



