125 Polyene Macrolides 



Streptomyces noursei 



Elizabeth L. Hazen and Rachel Brown, Proc. Soc. Expl. 

 Biol. Med. 76 93 (1951). 



James D. Dutcher, Gerald Boyack and Sidney Fox, "Anti- 

 biotics Annual 1953-1954," Medical Encyclopedia, Inc., New 

 York, p. 191. 



David R. Walter, James D. Dutcher and O. Wintersteiner, 

 ;. Am. Chem. Soc. 79 5076 (1957). (Structure) 



231 Rimocidin (Sulfate heptahydrate), large fragile plates, m.p. 



^151° (dec.), [aW (sulfate) +75° (c 1 in methanol). 



An amphoteric tetraene. U.V. maxima at: 279, 291, 

 304, 318 m/x. Analysis (hydrated sulfate): C 57.65, H 

 7.82, N 1.81, S 2.03. 



Streptomyces rimosus 



J. W. Davlsson, F. W. Tanner, Jr., A. C. Finlay and I. A. 

 Solomons, Antibiotics and Chemotherapy 1 289 (1951). 



232 Protocidin, m.p. dec. from 120°. 



A polyene antifungal agent. U.V. maxima 277, 290, 

 303 and 318 mpi. Reduces KMn04. Green Fehling. Neg- 

 ative biuret, Sakaguchi, Molisch, ninhydrin, anthrone, 

 FeCL. 



Streptomyces sp. 



The yield was about 100 mg. per liter. 



Jean Marie Sakimoto, J. Antibiotics (Japan) lOA 128 

 (1957). 



233 Amphotericin-A, m.p. gradual dec. above 153°, [(x]o^^"^ +32° (in 



acid dimethylformamide). 



An amphoteric tetraene. U.V. maxima: 291, 305, 320 

 mix. Analysis: C 60.32, H 8.39, N 1.72. 



Streptomyces sp. 



J. Vandeputte, J. L. Wachtel and E. T. Stiller, "Antibiotics 

 Annual 1955-1956," Medical Encyclopedia, Inc., New York, 

 p. 587. 



234 Sistomycosin, bufp or light yellow microcrystals, m.p. --'230° 



(browning from 130°). 



A neutral tetraene. U.V. maxima: 218, 292.5, 306, 

 320.5 m^ in aqueous solution. Positive Benedict and 

 Molisch tests. 



Streptomyces viridosporus n. sp. 



J. Ehrlich, M. Knudsen and Q. Bartz, Canadian Patent 

 514,894 (1955). 



235 Endomycin A (Helixin A), yellow-brown powder. 



An acidic tetraene. U.V. maxima at 292, 301, 319 mix. 

 Streptom.yces hygroscopicus (S. endus) 

 A yield of 11.7 g. of mixed endomycins from about 15 

 liters of broth has been reported. 



