127 Polyene Macrolides 



bert E. Carter and George B. Whitfield, Phytopathology 45 559 

 (1955). 



Belig Berkoz and Carl Djerassi, Proc. Chem. Soc, 316 

 (1959). (Structure) 



239 Fungichromin, C;{.-,H,i,,0,;!, pale yellow crystals, m.p. 205-210°. 



A pentaene. U.V. maxima: 322.5, 338.5, 356.5 m^. 

 The following moiety has been obtained by alkaline hy- 

 drolysis followed by periodate oxidation: 



OHC— C=CH(CH=CH)4— CHO 



CH:, 



Streptomyces cellidosae 



A similar substance, fungichromatin, occurred in the 

 same culture. 



Alfred A. Tytell, Frank J. McCarthy, W. P. Fisher, Wil- 

 liam A. Balhofer and Jesse Charney, "Antibiotics Annual 

 1954-1955," Medical Encyclopedia, Inc., New York, p. 716. 



Arthur C. Cope and Herbert E. Johnson, /. Am. Chem. Soc. 

 80 1504 (1958). 



240 PA-153, C:i7H,;,Oi4N (proposed), colorless powder, m.p. gradual 



dec. up to 260° ( triethylamine salt dec. 126-129°), [x]^-^ 

 -f398° (c 0.2 in pyridine). 



An amphoteric pentaene. U.V. maxima: 303, 317, 

 332, 349 in aqueous methanol. Positive ninhydrin, 2,4- 

 DNPH and Fehlings tests. Three C-methyl groups. 



Streptomyces n. sp. 



B. K. Koe, F. W. Tanner, Jr., K. V. Rao, B. A. Sobin and 

 W. D. Celmer, "Antibiotics Annual 1957-1958," Medical En- 

 cyclopedia, Inc., New York, p. 897. 



241 Pentamycin, pale yellow needles, m.p. 237° (dec). 



An antifungal pentaene antibiotic resembling filipin in 

 some properties. U.V. maxima at: 322, 338, 356 m^. 

 Contains only C, H, O. 



About 60 g. of fairly pure material were obtained from 

 100 liters of culture (mycelium). 



Streptomyces penticus 



Sumio Umezawa and Yoshiaki Tanaka, /. Antibiotics (Ja- 

 pan) llA 26 (1958). 



242 Eurocidin. 



A pentaene. U.V. maxima: 318, 333, 351 m^x. 



