129 Polyene Macrolides 



247 Helixins. 



A complex of three or four compounds. Helixin B is 

 identical with endomycin B. 



Streptomyces sp. 



Curt Leben, G. J. Stessel and G. W. Keitt, Mycologia 44 159 

 (1952). 



248 Amphotericin-B, doHy^OooN (tentative) deep yellow prisms or 



needles from dimethylformamide, m.p: gradual dec. above 

 170°, [ajp +333° (in acid dimethylformamide). 



An amphoteric heptaene, U.V. maxima at: 364, 383, 

 408 m^. Contains a mycosamine moiety: 



Streptomyces nodosiis 



J. Vandeputte, J. L. Wachtel and E. T. Stiller, "Antibiotics 

 Annual 1955-1956," Medical Encyclopedia, Inc., New York, 

 p. 587. (Isolation) 



David R. Walters, James D. Dutcher and O. Wintersteiner, 

 J. Am. Chem. Soc. 79 5076 (1957). (Structure) 



249 Zaomycin, m.p. 242-246° (dec). 



An amphoteric antibiotic said to resemble amphotericin. 

 Positive ninhydrin, Millon, biuret, FeClo tests. Negative 

 Fehling and Liebermann reactions. 



Streptomycin zaomyceticus 



Yorio Hinuma, J. Antibiotics (Japan) 7A 134 (1954). 



250 PA-150, Cr,4H820i8N2 (proposed), yellow powder, m.p. gradual 



dec. up to 260°, [ajrr' +294° (c 0.2 in pyridine). 



An amphoteric heptaene. U.V. maxima: 340, 358, 

 377, 397 m^ in aqueous methanol. Positive 2,4-DNPH 

 and Fehlings tests. Four C-methyl groups. 



Streptomyces n. sp. 



B. K. Koe, F. W. Tanner, Jr., K. V. Rao, B. A. Sobin and 

 W. D. Celmer, "Antibiotics Annual 1957-1958," Medical En- 

 cyclopedia, Inc., New York, p. 897. 



251 Trichomycin, yellow powder, m.p. 155° (dec). 



A heptaene. U.V. maxima: 286, 346, 364, 384, 405 

 rufx. May be a mixture of two heptaenes. 

 Streptomyces hachijoensis n. sp. 



