Pfizer Handbook of Microbial Metabolites 130 



Seigo Hosoya, Nobuhiko Komatsu, Momoe Soeda and Yoko 

 Sonoda, Japan J. Exptl. Med. 22 505 (1952). 



Seigo Hosoya, Nobuhiko Komatsu, Momoe Soeda, Tatsuro 

 Yuwaguchi and Yoko Sonoda, 7. Antibiotics (Japan) 5 564 

 (1952). 



252 Candidin, yellow powder. 



Acidic heptaene. U.V. maxima: (Na salt) 234, 282, 

 345, 360, 383, 405 m^i in aqueous solution. The free acid 

 lacks the 345 peak. Contains nitrogen and gives positive 

 ketone tests. 



Streptomyces viridofiavus 



Willard A. Taber, Leo C. Vining and Selman A. Waksman, 

 Antibiotics and Chemotherapy 4 455 (1954). 



Leo C. Vining, Willard A. Taber and Francis J. Gregory, 

 "Antibiotics Annual 1954— 1955, ' Medical Encyclopedia, Inc., 

 New York, p. 980. 



Candicidins. 



Heptaenes. U.V. maxima: 



253 Candicidin A: 360, 380, 403 m/x. 



254 Candicidin B: 362, 381, 404 m^. 



255 Candicidin C: 358, 379, 402 m/x. 



Streptomyces griseus, other Streptomyces spp. 

 Hubert A. Lechevalier, R. F. Acker, C. T. Corke, C. M. 

 Haenseler and S. A. Waksman, Mycologia 45 155 (1953). 



256 Ascosin, yellow-orange powder. 



A weakly acidic heptaene. U.V. maxima: 234, 288, 

 340, 357, 376, 398 m/x in methanol. 



Streptomyces canescus 



Richard J. Hickey, Cyril J. Corum, Phil H. Hidy, I. Ray 

 Cohen, Urs F. B. Nager and Eleonore Kropp, Antibiotics and 

 Chemotherapy 2 472 (1952). 



Isadore R. Cohen, U. S. Patent 2,723,216, (1955). 



h. OTHER MACROLIDES 



257 Nitrosporin, C^oH^eOfiNo, colorless crystals, m.p. 130-140° 

 (dec). Crystals brown on exposure to air. 



A basic substance, apparently a macrolide. 



Streptomyces nitrosporeus 



Hamao Umezawa and Tomio Takeuchi, /. Antibiotics (Ja- 

 pan) 5 270 (1952). 



