131 



Other Macrolides 



258 Celesticetin I, amphoteric, crystaUine and dextrorotatory, 



Co4H3^.4„Ot,N2S (suggested empirical formula). Oxalate 

 and Salicylate water soluble. Oxalate m.p. 149-154°; 

 Salicylate m.p. 139° (tabular monoclinic crystals). 



Erythromycin-hke. (See entry 923, however) 



Positive tests — FeCla, Molisch, Ekkert 



White ppt. — Bro water, Millon's Reagent, HgCL 



Negative tests — AgNOg, PbAc, Benedict, ninhydrin, io- 

 doform, nitroprusside (becomes + after standing several 

 days in 6 N hydrochloric acid) 



No immediate reaction with Br^ — CCI4. 



Streptomyces caelestis 



Herman Hoeksema, Glen F. Crum, William H. DeVries, 

 Antibiotics Annual 2 837-841 (1954-1955). (Isolation and 

 purification ) 



259 Amaromycin, C^.-.H^^OyN (proposed), colorless prisms, m.p. 



164.5°, [a]n'' +6.19° (c 1 in ethanol). 



Basic substance, analysis: C 63.66, H 8.73, N 3.0. 

 Negative FeCl-^, biuret, ninhydrin, Sakaguchi, Schiff. 

 Positive Tollens, Fehlings. Precipitated by Reinecke's 

 salt. Probably a macrolide. 



Streptomyces flavochromogenes 



Toju Hata, Yashimoto Sano, Hideo Tatsuta, Ryazo Suga- 

 wara, Akihiro Matsumae and Kokichi Kanamori, /. Antibiotics 

 (Japan) 8A 9 (1955). 



260 



261 



PA-133 A, C2r,H430eN, colorless amorphous solid, [a]n'' +39.6° 

 (c 0.5 in methanol). 



A macrolide antibiotic. 



Streptoviyces sp. 



K. Murai, B. A. Sobin, W. D. Celmer and F. W. Tanner, 

 Antibiotics and Chemotherapy 9 485 (1959). 



Methymycin, C05H43O7N, colorless prisms 

 1 Q70 rnn'io\ [1 23 



197° (203°), [a],,-' +61' 



, needles, m.p. 195— 

 (in methanol). 



Desosamine 



