133 Other Macrolides 



264 PA-133-B, Cor.Hj-OioN, colorless crystals, m.p. 99.8-101°, [ajn'' 



+ 22.5° (c 0.5 in methanol). 



A macrolide antibiotic. 



Streptoviyces sp. 



K. Mural, B. A. Sobin, W. D. Celmer and F. W. Tanner, 

 Antibiotics and Chemotherapy 9 485 (1959). 



265 Griseomycin (Lomycln) (Hydrochloride) C25H4g08NCl, white 



powder, m.p. 76-80° (dec), [a]n'' +32° (c 1 in chloro- 

 form). 



Precipitated by Reinecke salt, bromine water, picric 

 acid. Thought to be a macrolide. 



Streptomyces griseolus 



P. J. Van Dijck, H. P. Van de Voorde and P. DeSomer, Anti- 

 biotics and Chemotherapy 3 1243 (1953). 



Ibid. Belgian Patent 522,647 (1954). 



266 Proactinomycin A, C27H47OSN (proposed), colorless crystals, 



m.p. 168°. 



267 Proactinomycin B, Co^H4c,OsN (proposed), colorless crystals, 



m.p. 83-87°. 



268 Proactinomycin C, C24H41O6N (proposed), amorphous. 



Basic substances, precipitated by Reineckes salt, picric 

 or flavianic acids, etc. Probably macrolides. 



Nocardia gardneri 



A. D. Gardner and E. Chain, Brit. J. Exptl. Path. 23 123 

 (1942). 



R. Q. Marston, ibid. 30 398 (1949). (Isolation) 



Antimycins (Antipiriculins)* 



269 Antimycin A^, C28H40O9N2, colorless crystals, m.p. 149-150°, 



[ix]t>'^' +76 (c 1 in chloroform). 



270 Antimycin Aoa, Cor,H3609N2, colorless crystals, m.p. 143-149°, 



271 Antimycin A^^ (may be isomeric with A2a), colorless crystals, 



m.p. 168°. 



272 Antimycin A3 (Blastmycin), C20H3BO9N2, colorless crystals, m.p. 



170.5-171.5°, [x]rr'= +64.3° (c 1 in chloroform). 



* The antimycins might also be classified as depslpeptldes (pepto- 

 hdes). 



