Pfizer Handbook of Microbial Metabolites 134 



273 Antimycin A4, oily. 



CHj 



O 



O CH3 



NH OH \ / 



/ CH CH 



OHC ^ V r^ ^^ R = n— CeHia in Ai. 



CH3 ^ '\ R = n — C4H9 in A3. 



O 



At least seven streptomyces species produce antimy- 

 cins, including S. kitazawaensis Harada et Tanaka nov. 

 sp. and S. blastmyceticus. The former organism also pro- 

 duces carzinocidin. Blastmycin is identical with anti- 

 mycin A;(. Virosin is probably a mixture of antimycin 

 components. Certain antimycin-producing cultures also 

 contain actinomycin B. 



Wen-chik Liu and F. M. Strong, J. Am. Chem. Soc. 81 4387 

 (1959). 



Wen-chik Liu, E. E. Van Tamelen and F. M. Strong, ibid. 

 82 1652 (1960). (Degradations, etc.) 



F. M. Strong, J. P. Dickie, M. E. Loomans, E. E. Van 

 Tamelen and R. S. Dewey, ibid. 82 1513 (1960). (Structure) 



Bryant R. Dunshee, Curt Leben, G. W. Keitt and F. M. 

 Strong, ibid. 71 2436 (1949). (Isolation) 



Yoshio Sakagami, Setsuo Takeuchi, Hiroshi Yonehara, 

 Heiichi Sakai and Matso Takashima, J. Antibiotics (Japan) 

 9A 1 (1956). 



Kiyoshi Nakayama, Fukusaburo Okamoto and Yujiro 

 Harada, ibid. 9A 63 (1956). 



Yujiro Harada, Keizo Uzu and Masaru Asai, ibid. IIA 32 

 (1958). 



Hiroshi Yonehara and Setsuo Takeuchi, ibid. IIA 122 

 (1958). (Proposed structure) 



Kiyoshi Watanabe, Tsutomo Tanaka, Keiko Fukuhara, 

 Norisama Miyairi, Hiroshi Yonehara and Hamao Umezawa, 

 ibid. lOA 39 (1957). 



F. M. Strong, "Topics in Microbial Chemistry" (Squibb 

 Lectures on the Chemistry of Microbial Products), John Wiley 

 and Sons, Inc., New York, 1956, pp. 1-44. (A review to that 

 date) 



