Pfizer Handbook of Microbial Metabolites 



144 



has been studied.'' ^-Ketoadipic acid and S-chlorolevulinic acid 

 were found to be intermediates. The sequence shown here, 

 then, probably represents at least part of the biogenetic scheme 

 for this metabolite. 



COOH 



I 

 OH CH2 



I I 



o=c c=o 



CHo— CH2 

 /3-Ketoadipic Acid 



5-Chlorolevulinic Acid 



Caidariomycin 



Palitantin appears to be an interesting example of an un- 

 aromatized acetate derivative. Its origin is revealed by the 14- 

 carbon atoms, the uneven-numbered side-chains and the pattern 

 of oxidation and unsaturation. 



The cycloheximides also seem to be acetate derivatives, al- 

 though apparently no study of their biosynthesis has been pub- 

 lished. 



Without having made a detailed analysis of the experimental 

 work it would seem that the proposed structures for the glau- 

 conic acids are unique if not improbable. 



293 Caidariomycin,- CgHsOoClo, colorless needles, m.p. 121°, [a]r,46i^'' 

 +59.2° (c 0.338 in water). 



CI 



CI 



HCOH 



I 

 -CH2 



HOCH 

 CH2— 



Caldariomyces fumago 



* Paul D. Shaw, Jonathon R. Beckwith and Lowell P. Hager, /. Biol. 

 Chem. 234 2560 (1959). 



