J 79 



Terpenoids and Steroids 



367 Helvolic Acid (Fumigacin, May = Mycocidin), C;{2H420s, color- 

 less fine needles, m.p. 211° (dec). [oc]u-'' -124° (in chlo- 

 roform ) . 



Tentative partial structure: 



HOOC 



^— CHo— 



Aspergillus fuinigatus mut. helvola Yuill 



Donald J. Cram and Norman L. Allinger, /. Am. Chem. Soc. 

 78 5275 (1956). (Structure) 



E. Chain, H. W. Florey, M. A. Jennings and T. 1. Williams, 

 Brit. ]. Exp. Pathol. 24 108 (1943). (Isolation) 



CIBA Lectures in Microbial Chemistry, E. P. Abraham, 

 "Biochemistry of Some Peptide and Steroid Antibiotics," The 

 cephalosporins, John Wiley and Sons, New York, 1957, pp. 

 30-63. (A review) 



Cephalosporins P 



These non-peptide compounds accompany cephalospo- 

 rins N and C in Cephalosporium salmosynnematum fer- 

 mentations. 



TABLE I 



368 



369 

 370 



371 



Cephalosporin Pj resembles helvolic acid (from Asper- 

 gillus fuinigatus). A complete (steroid) structure has 

 been determined by T. G. Halsall and associates, but has 

 not been published yet. 



