Pfizer Handbook of Microbial Metabolites 194 



Otto Neubauer and L. Flatow, Hoppe-Seyler's Zeitschrift 

 fiirphysiol. Chem. 52 375 (1907). 



G. F. J. Moir and B. F. Ralph, Chem. and Ind., 1143 (1954). 



385 3-Hydroxyphthalic Acid, CsHeO^, colorless crystals m.p. : anhy- 

 dride formation near 150°, melting 166°. Sublimes. 



COOH 



COOH 



Penicillium islandicum, P. patulum 

 A yield of only 1-2 mg. per liter was obtained. 

 Sten Gatenbeck, Acta Chem. Scand. 11 555 (1957). 

 E. W. Bassett and S. W. Tanenbaum, Experientia 14 38 

 (1958). 



386 3,5-Dihydroxyphthalic Acid, CgHgOg, colorless prisms, m.p, 188° 

 (resolidifying at 206°). 



HO COOH 



OH <=°°" 



Penicillium brevi-compactum Dierckx 



Albert E. Oxford and Harold Raistrick, Biochem. J. 26 1902 



(1932). (Isolation) 



John Howard Birkinshaw and Arthur Bracken, J. Chem,. 



Soc, 368 (1942). (Synthesis) 



387 2,4,5-Trihydroxyphenylglyoxylic Acid, CgHgOe, bright red prisms, 

 m.p. 193°. 



O 



OH II 



C— COOH 



Polyporus tumulosus (artificial medium) 

 Homoprotocatechuic acid and oxalic acid were present 

 in the same culture. 



