Pfizer Handbook of Microbial Metabolites 222 



464 Barbatic Acid (Rhizoic Acid, Coccellic Acid), C19H20O7, colorless 

 prisms, m.p. 187° (dec.)- 



CH3O I OH I COOH 



Cladonia fioerkeana Sommerf., CI. bacillaris Nyl., CI. 

 macilenta (Hoff. ) Flk., CI. coccifera (L. ), CI. amauro- 

 craea (Fl.) Schaer., Rhizocarpon geographicum (L.), Us- 

 nea longissima Ach. 



Usnic acid also was present. 



Fukuziro Fuzikawa, /. Pharm. Soc. Japan 56 237 (in Ger- 

 man, 25) (1936). (Synthesis) 



465 Physodalic Acid (Monoacetylprotocetraric Acid), CooHjeOio, col- 

 orless plates, m.p. 260° (dec. from 230°). 



CH3 ^^^ CH.OCOCH3 

 COO I OH 



HO I \r,/ i COOH 



CHO O 



Parmelia physodes Ach., P. hypotrypella Asahina 

 Wilhelm Zopf, Ann. 295 287 (1897). 

 Idem., ibid. 300 350 (1898). 



466 Nidulin, CooHi^O.-.CL^, colorless crystals, m.p. 180°. 



O 



... II 



CI T c— o I 0CH3 



CsH, 



Aspergillus nidulans NRRL, No. 2006 



The yield was about 6 g. from 126 g. of dry mycelium; 

 a little mannitol also was found. 



F. M. Dean, John C. Roberts and Alexander Robertson, J. 

 Chem. Soc, 1432 (1954). 



